Impact of Oxypurinol in Patients With Symptomatic Heart Failure. Results of the OPT-CHF Study

Joshua M. Hare, Brian Mangal, Joanne Brown, Charles Fisher, Ronald Freudenberger, Wilson S. Colucci, Douglas L. Mann, Peter Liu, Michael M. Givertz, Richard P. Schwarz

Research output: Contribution to journalArticlepeer-review

284 Scopus citations


Objectives: This study evaluated whether a xanthine oxidase (XO) inhibitor, oxypurinol, produces clinical benefits in patients with New York Heart Association functional class III to IV heart failure due to systolic dysfunction receiving optimal medical therapy. Background: Increased XO activity may contribute to heart failure pathophysiology. Methods: Patients (n = 405) were randomized to oxypurinol (600 mg/day) or placebo. Efficacy at 24 weeks was assessed using a composite end point comprising heart failure morbidity, mortality, and quality of life. Results: The percentage of patients characterized as improved, unchanged, or worsened did not differ between those receiving oxypurinol or placebo. Oxypurinol reduced serum uric acid (SUA) by ∼2 mg/dl (p <0.001). In a subgroup analysis, patients with elevated SUA (>9.5 mg/dl, n = 108) responded favorably to oxypurinol (p = 0.02 for interaction term), whereas oxypurinol patients with SUA

Original languageEnglish (US)
Pages (from-to)2301-2309
Number of pages9
JournalJournal of the American College of Cardiology
Issue number24
StatePublished - Jun 17 2008
Externally publishedYes

ASJC Scopus subject areas

  • Nursing(all)


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