TY - JOUR
T1 - Impact of neonatal vitamin A supplementation on infant morbidity and mortality
AU - Humphrey, J. H.
AU - Agoestina, T.
AU - Wu, L.
AU - Usman, A.
AU - Nurachim, M.
AU - Subardja, D.
AU - Hidayat, S.
AU - Tielsch, J.
AU - West, K. P.
AU - Sommer, A.
N1 - Funding Information:
The study was reviewed and approved by the Joint Committee on Clinical Investigation at Johns Hopkins University School of Medicine, Baltimore, Md.; the Ethical Review Committee of Hasan Sadikin Hospital, Bandung, Indonesia; and the Indonesian Ministry of Health in Jakarta.
PY - 1996
Y1 - 1996
N2 - Objective: To determine whether vitamin A supplementation at birth could reduce infant morbidity and mortality. Study design: We conducted a placebo- controlled trial among 2067 Indonesian neonates who received either 52 μmol (50,000 IU) orally administered vitamin A or placebo on the first day of life. Infants were followed up at 1 year to determine the impact of this intervention on infant mortality. A subgroup (n = 470) was also examined at 4 and 6 months of age to examine the impact on morbidity. Results: Vital status was confirmed in 89% of infants in both groups at 1 year. There were 19 deaths in the control group and 7 in the vitamin A group (relative risk = 0.36; 95% confidence interval = 0.16, 0.87). The impact was stronger among boys, infants of normal compared with low birth weight, and those of greater ponderal index. Among infants examined at 4 months of age, the 1-week period prevalence of common morbidities was similar for vitamin A and control infants. However, during this same 4-month period, 73% and 51% more control infants were brought for medical treatment for cough (p=0.008) and fever (p=0.063), respectively. Conclusions: Neonatal vitamin A supplementation may reduce the infant mortality rate and the prevalence of severe respiratory infection among young infants.
AB - Objective: To determine whether vitamin A supplementation at birth could reduce infant morbidity and mortality. Study design: We conducted a placebo- controlled trial among 2067 Indonesian neonates who received either 52 μmol (50,000 IU) orally administered vitamin A or placebo on the first day of life. Infants were followed up at 1 year to determine the impact of this intervention on infant mortality. A subgroup (n = 470) was also examined at 4 and 6 months of age to examine the impact on morbidity. Results: Vital status was confirmed in 89% of infants in both groups at 1 year. There were 19 deaths in the control group and 7 in the vitamin A group (relative risk = 0.36; 95% confidence interval = 0.16, 0.87). The impact was stronger among boys, infants of normal compared with low birth weight, and those of greater ponderal index. Among infants examined at 4 months of age, the 1-week period prevalence of common morbidities was similar for vitamin A and control infants. However, during this same 4-month period, 73% and 51% more control infants were brought for medical treatment for cough (p=0.008) and fever (p=0.063), respectively. Conclusions: Neonatal vitamin A supplementation may reduce the infant mortality rate and the prevalence of severe respiratory infection among young infants.
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U2 - 10.1016/S0022-3476(96)70359-1
DO - 10.1016/S0022-3476(96)70359-1
M3 - Article
C2 - 8618182
AN - SCOPUS:9244240738
VL - 128
SP - 489
EP - 496
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 4
ER -