Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases

Luis M.F. Gonzalez, Rodrigo M. Brindeiro, Renato S. Aguiar, Helena S. Pereira, Celina M. Abreu, Marcelo A. Soares, Amilcar Tanuri

Research output: Contribution to journalArticlepeer-review

Abstract

Human immunodeficiency virus type 1 subtype B and C proteases were manipulated to contain 90M, 88D, or 89L, and their in vitro biological properties were studied. We showed that D30N has significantly more impact in subtype C than in subtype B counterparts, accounting for the reported low prevalence of this mutation in patients failing nelfanavir-based regimens.

Original languageEnglish (US)
Pages (from-to)3552-3555
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume48
Issue number9
DOIs
StatePublished - Sep 2004
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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