Impact of maternal human immunodeficiency virus infection on pregnancy and birth outcomes in Pune, India

Sandesh Patil, Ramesh Bhosale, Pradeep Sambarey, Nikhil Gupte, Nishi Suryavanshi, Jayagowri Sastry, Robert C Bollinger, Amita Gupta, Anita V Shankar

Research output: Contribution to journalArticle

Abstract

Little is known about birth outcomes for HIV-infected women in India. We examine maternal and neonatal birth outcomes in HIV-infected women within the context of enhanced pre-natal care associated with a randomized clinical trial conducted in Pune, India. Birth outcomes of 212 HIV-infected pregnant women were compared with those of 130 HIV-uninfected pregnant women attending a government tertiary care hospital between 2002 and 2004. These women and children were participating in the Six Week Extended-Dose Nevirapine (SWEN) study. Birth outcomes and maternal morbidity data were collected at delivery. We found no differences between HIVinfected and uninfected pregnant women with respect to the proportion with elevated intrapartum blood pressure, eclampsia, oligohydramnios, intrauterine growth restriction (IUGR), preterm delivery, or caesarean section (p>0.05). HIV-infected women were more likely to have peri-partum fever (3% versus 0%, p>0.04). There were no differences in neonatal parameters such as low birth weight (LBW), infants who were small for gestational age, or those having congenital anomalies (p>0.05). Compared with infants of HIV-infected women enrolled antenatally, infants of HIV-infected women enrolled in the post-partum ward had a higher risk of preterm delivery (20% versus 8%, p>0.02) and LBW (41% versus 22%, p>0.002). HIV-infected women in this cohort in India were not found to have significant negative birth outcomes. Antenatal care was important as those not having received any antenatal care prior to deliver were at increased risk of having a pre-term delivery or an infant with LBW. Based on these data, regular antenatal care provided to HIV-infected women can reduce risk of adverse birth outcomes for their infants.

Original languageEnglish (US)
Pages (from-to)1562-1569
Number of pages8
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume23
Issue number12
DOIs
StatePublished - Dec 2011

Fingerprint

Virus Diseases
Pregnancy Outcome
pregnancy
India
Mothers
HIV
Parturition
Prenatal Care
infant
Low Birth Weight Infant
Pregnant Women
Oligohydramnios
Nevirapine
Eclampsia
Tertiary Healthcare
Tertiary Care Centers
Cesarean Section
Gestational Age
Fever
Randomized Controlled Trials

Keywords

  • Antenatal care
  • Birth outcomes
  • Infant and maternal health

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Social Psychology

Cite this

Impact of maternal human immunodeficiency virus infection on pregnancy and birth outcomes in Pune, India. / Patil, Sandesh; Bhosale, Ramesh; Sambarey, Pradeep; Gupte, Nikhil; Suryavanshi, Nishi; Sastry, Jayagowri; Bollinger, Robert C; Gupta, Amita; Shankar, Anita V.

In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Vol. 23, No. 12, 12.2011, p. 1562-1569.

Research output: Contribution to journalArticle

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