Impact of maternal HIV infection on obstetrical and early neonatal outcome

M. R. Braddick, J. K. Kreiss, J. E. Embree, P. Datta, J. O. Ndinya-Achola, H. Pamba, G. Maitha, P. L. Roberts, T. C. Quinn, K. K. Holmes, G. Vercauteren, P. Piot, M. W. Adler, F. A. Plummer

Research output: Contribution to journalArticle

Abstract

In a case-control study of 177 HIV-seropositive and 326 seronegative women and their newborns in Nairobi, Kenya, maternal HIV infection at term was independently associated with travel to other African countries [odds ratio (OR) 4.9, P < 0.0001], history of a blood transfusion since 1980 (OR 3.5, P = 0.01), history of more than one sexual partner in the previous 5 years (OR 1.8, P = 0.02) and unmarried status (OR 1.8, P = 0.02). Neonates of HIV-positive and HIV-negative women differed little with respect to occurrence of congenital malformations, stillbirths, in-hospital mortality, sex, APGAR score, or gestational age. However, the mean birth weight of singleton neonates of HIV-positive women was significantly lower than that of controls (3090 versus 3220 g, P = 0.005), and birth weight was < 2500 g in 9% of cases and 3% of controls (OR 3.0, P = 0.007). Among neonates of HIV-seropositive women, birth weight was < 2500 g in 17% if mothers were symptomatic and 6% if mothers were asymptomatic (OR 3.4, P = 0.08).

Original languageEnglish (US)
Pages (from-to)1001-1005
Number of pages5
JournalAIDS
Volume4
Issue number10
DOIs
StatePublished - 1990

Keywords

  • Africa
  • HIV
  • birth weight
  • pregnancy
  • vertical transmission
  • women

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    Braddick, M. R., Kreiss, J. K., Embree, J. E., Datta, P., Ndinya-Achola, J. O., Pamba, H., Maitha, G., Roberts, P. L., Quinn, T. C., Holmes, K. K., Vercauteren, G., Piot, P., Adler, M. W., & Plummer, F. A. (1990). Impact of maternal HIV infection on obstetrical and early neonatal outcome. AIDS, 4(10), 1001-1005. https://doi.org/10.1097/00002030-199010000-00009