Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection

Hugh R. Taylor, Michel Pacqué, Beatriz Munoz, Bruce M. Greene

Research output: Contribution to journalArticle

Abstract

Onchocerciasis is a major blinding disease that, until recently, has been essentially untreatable. Ivermectin is a safe and effective drug for the mass treatment of onchocerciasis and when used on an individual basis, it reduces the ability of the treated person to transmit Onchocerca volvulus infection. In the present study, the effect of community-based ivermectin treatment on the degree of transmission within the community was assessed by determining the incidence of new infection in children. Ivermectin was distributed annually on three occasions to the eligible members of a population of approximately 14,000 people living on a rubber plantation in a forest area endemic for onchocerciasis. After 2 years, the prevalence of infection in 5-year-old children decreased by 21%. The annual incidence in an uninfected cohort of children decreased by 35% and, after age-specific adjustment, the reduction in incidence in 7- to 12-year-old children was 45%. Thus, community-based distribution of ivermectin led to a significant reduction in incidence of new infection. These findings suggest that ivermectin can be important in reducing the transmission of onchocerciasis.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalScience
Volume250
Issue number4977
StatePublished - 1990

Fingerprint

Onchocerciasis
Ivermectin
Infectious Disease Transmission
Incidence
Infection
Onchocerca volvulus
Therapeutics
Rubber
Delivery of Health Care
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • General

Cite this

Taylor, H. R., Pacqué, M., Munoz, B., & Greene, B. M. (1990). Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection. Science, 250(4977), 116-118.

Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection. / Taylor, Hugh R.; Pacqué, Michel; Munoz, Beatriz; Greene, Bruce M.

In: Science, Vol. 250, No. 4977, 1990, p. 116-118.

Research output: Contribution to journalArticle

Taylor, HR, Pacqué, M, Munoz, B & Greene, BM 1990, 'Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection', Science, vol. 250, no. 4977, pp. 116-118.
Taylor, Hugh R. ; Pacqué, Michel ; Munoz, Beatriz ; Greene, Bruce M. / Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection. In: Science. 1990 ; Vol. 250, No. 4977. pp. 116-118.
@article{2992a03286a24d3ea3e3d4fb265cb0ce,
title = "Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection",
abstract = "Onchocerciasis is a major blinding disease that, until recently, has been essentially untreatable. Ivermectin is a safe and effective drug for the mass treatment of onchocerciasis and when used on an individual basis, it reduces the ability of the treated person to transmit Onchocerca volvulus infection. In the present study, the effect of community-based ivermectin treatment on the degree of transmission within the community was assessed by determining the incidence of new infection in children. Ivermectin was distributed annually on three occasions to the eligible members of a population of approximately 14,000 people living on a rubber plantation in a forest area endemic for onchocerciasis. After 2 years, the prevalence of infection in 5-year-old children decreased by 21{\%}. The annual incidence in an uninfected cohort of children decreased by 35{\%} and, after age-specific adjustment, the reduction in incidence in 7- to 12-year-old children was 45{\%}. Thus, community-based distribution of ivermectin led to a significant reduction in incidence of new infection. These findings suggest that ivermectin can be important in reducing the transmission of onchocerciasis.",
author = "Taylor, {Hugh R.} and Michel Pacqu{\'e} and Beatriz Munoz and Greene, {Bruce M.}",
year = "1990",
language = "English (US)",
volume = "250",
pages = "116--118",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4977",

}

TY - JOUR

T1 - Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection

AU - Taylor, Hugh R.

AU - Pacqué, Michel

AU - Munoz, Beatriz

AU - Greene, Bruce M.

PY - 1990

Y1 - 1990

N2 - Onchocerciasis is a major blinding disease that, until recently, has been essentially untreatable. Ivermectin is a safe and effective drug for the mass treatment of onchocerciasis and when used on an individual basis, it reduces the ability of the treated person to transmit Onchocerca volvulus infection. In the present study, the effect of community-based ivermectin treatment on the degree of transmission within the community was assessed by determining the incidence of new infection in children. Ivermectin was distributed annually on three occasions to the eligible members of a population of approximately 14,000 people living on a rubber plantation in a forest area endemic for onchocerciasis. After 2 years, the prevalence of infection in 5-year-old children decreased by 21%. The annual incidence in an uninfected cohort of children decreased by 35% and, after age-specific adjustment, the reduction in incidence in 7- to 12-year-old children was 45%. Thus, community-based distribution of ivermectin led to a significant reduction in incidence of new infection. These findings suggest that ivermectin can be important in reducing the transmission of onchocerciasis.

AB - Onchocerciasis is a major blinding disease that, until recently, has been essentially untreatable. Ivermectin is a safe and effective drug for the mass treatment of onchocerciasis and when used on an individual basis, it reduces the ability of the treated person to transmit Onchocerca volvulus infection. In the present study, the effect of community-based ivermectin treatment on the degree of transmission within the community was assessed by determining the incidence of new infection in children. Ivermectin was distributed annually on three occasions to the eligible members of a population of approximately 14,000 people living on a rubber plantation in a forest area endemic for onchocerciasis. After 2 years, the prevalence of infection in 5-year-old children decreased by 21%. The annual incidence in an uninfected cohort of children decreased by 35% and, after age-specific adjustment, the reduction in incidence in 7- to 12-year-old children was 45%. Thus, community-based distribution of ivermectin led to a significant reduction in incidence of new infection. These findings suggest that ivermectin can be important in reducing the transmission of onchocerciasis.

UR - http://www.scopus.com/inward/record.url?scp=0025049065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025049065&partnerID=8YFLogxK

M3 - Article

VL - 250

SP - 116

EP - 118

JO - Science

JF - Science

SN - 0036-8075

IS - 4977

ER -