Impact of lung transplantation on serum lipids in COPD

Robert M. Reed, Salman Hashmi, Michael Eberlein, Aldo Iacono, Giora Netzer, Andrew Defilippis, Reda E. Girgis, Peter P. Toth, Steven Scharf, Steven Jones

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Severe chronic obstructive pulmonary disease is associated with high HDL cholesterol (HDL-C). We sought to examine the effect of lung transplantation on lipid profiles in patients with COPD. Methods: We analyzed 101 lung transplant recipients in a retrospective cohort of patients from two centers in whom lipid values were available both before as well as after transplantation. Sixty-one subjects were transplanted for severe COPD (93% GOLD stage 4). Results: Eighty-nine percent of subjects with COPD exhibited a decline in HDL-C. Median decline for the COPD cohort was 25 mg/dL (IQR 12-38 mg/dL, p < 0.0001). Non-COPD subjects exhibited no significant changes in HDL-C. Other lipid changes in the COPD cohort included a rise in triglycerides of 70 mg/dL (IQR 35 to 140, p < 0.0001). Decreases in HDL-C levels were independent from the rise in triglyceride levels. Neither LDL-C nor non-HDL-C demonstrated significant changes. Subjects with greater increases in prednisone exposure post-transplant exhibited lesser declines in HDL-C. Compared with tacrolimus, cyclosporine had no effect on observed changes in HDL-C or triglycerides, but was associated with a greater median rise in LDL-C. Conclusions: In patients with COPD, lung transplantation results in reductions in the serum levels of HDL-C. These changes are not observed in patients undergoing lung transplantation for diagnoses other than COPD.

Original languageEnglish (US)
Pages (from-to)1961-1968
Number of pages8
JournalRespiratory Medicine
Volume105
Issue number12
DOIs
StatePublished - Dec 2011

Keywords

  • COPD
  • Cholesterol
  • HDL
  • Lipoproteins
  • Lung transplantation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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