Impact of left ventricular volume/mass ratio on diastolic function

Adisai Buakhamsri, Zoran B. Popović, Jingna Lin, Pascal Lim, Neil L. Greenberg, Allen G. Borowski, W. H Wilson Tang, Allan L. Klein, Harry M. Lever, Milind Y. Desai, James D. Thomas

Research output: Contribution to journalArticle

Abstract

Aims: To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls.Methods and resultsWe performed echocardiography in 44 healthy controls, 35 HCM subjects, 29 DCM subjects with narrow QRS complex (DCM-n), and 27 DCM subjects with wide QRS complex (DCM-w). Mitral annulus velocity (Ea) and transmitral E-wave velocity were used to estimate time constant of isovolumic pressure decay (τ). LV flow propagation velocity (Vp) and early intraventricular pressure gradient (IVPG) were derived from colour M-mode of LV inflow. We calculated LV twist and peak untwisting rate (UntwR) by speckle tracking. Mean LV volume/mass ratio was 0.34 ± 0.09 mL/g in healthy controls, 0.15 ± 0.06 mL/g in HCM, 0.6 ± 0.2 mL/g in DCM-n, and 0.8 ± 0.3 mL/g in DCM-w patients (P <0.001 for all groups). Resting LV ejection fractions were 63 ± 7, 64 ± 8, 31 ± 8, and 26 ± 8, respectively (P <0.01 vs. controls for DCM groups). In a multivariate analysis, LV volume/mass ratio remained a strong independent predictor of Vp (P <0.001), IVPG (P = 0.009), and UntwR (P <0.001) but not for Ea (P = 0.25).ConclusionLV volume/mass ratio had influences on diastolic function parameters independent of intrinsic diastolic function and filling pressures. It should be considered when assessing patients suspected of LV diastolic dysfunction.

Original languageEnglish (US)
Pages (from-to)1213-1221
Number of pages9
JournalEuropean Heart Journal
Volume30
Issue number10
DOIs
StatePublished - May 2009
Externally publishedYes

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Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Ventricular Pressure
Pressure
Left Ventricular Dysfunction
Stroke Volume
Echocardiography
Multivariate Analysis
Color

Keywords

  • Diastolic function
  • Dilated cardiomyopathy
  • Echocardiography
  • Hypertrophic cardiomyopathy
  • Left ventricular volume/mass ratio
  • Ventricular torsion (twist)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Buakhamsri, A., Popović, Z. B., Lin, J., Lim, P., Greenberg, N. L., Borowski, A. G., ... Thomas, J. D. (2009). Impact of left ventricular volume/mass ratio on diastolic function. European Heart Journal, 30(10), 1213-1221. https://doi.org/10.1093/eurheartj/ehp084

Impact of left ventricular volume/mass ratio on diastolic function. / Buakhamsri, Adisai; Popović, Zoran B.; Lin, Jingna; Lim, Pascal; Greenberg, Neil L.; Borowski, Allen G.; Tang, W. H Wilson; Klein, Allan L.; Lever, Harry M.; Desai, Milind Y.; Thomas, James D.

In: European Heart Journal, Vol. 30, No. 10, 05.2009, p. 1213-1221.

Research output: Contribution to journalArticle

Buakhamsri, A, Popović, ZB, Lin, J, Lim, P, Greenberg, NL, Borowski, AG, Tang, WHW, Klein, AL, Lever, HM, Desai, MY & Thomas, JD 2009, 'Impact of left ventricular volume/mass ratio on diastolic function', European Heart Journal, vol. 30, no. 10, pp. 1213-1221. https://doi.org/10.1093/eurheartj/ehp084
Buakhamsri A, Popović ZB, Lin J, Lim P, Greenberg NL, Borowski AG et al. Impact of left ventricular volume/mass ratio on diastolic function. European Heart Journal. 2009 May;30(10):1213-1221. https://doi.org/10.1093/eurheartj/ehp084
Buakhamsri, Adisai ; Popović, Zoran B. ; Lin, Jingna ; Lim, Pascal ; Greenberg, Neil L. ; Borowski, Allen G. ; Tang, W. H Wilson ; Klein, Allan L. ; Lever, Harry M. ; Desai, Milind Y. ; Thomas, James D. / Impact of left ventricular volume/mass ratio on diastolic function. In: European Heart Journal. 2009 ; Vol. 30, No. 10. pp. 1213-1221.
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abstract = "Aims: To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls.Methods and resultsWe performed echocardiography in 44 healthy controls, 35 HCM subjects, 29 DCM subjects with narrow QRS complex (DCM-n), and 27 DCM subjects with wide QRS complex (DCM-w). Mitral annulus velocity (Ea) and transmitral E-wave velocity were used to estimate time constant of isovolumic pressure decay (τ). LV flow propagation velocity (Vp) and early intraventricular pressure gradient (IVPG) were derived from colour M-mode of LV inflow. We calculated LV twist and peak untwisting rate (UntwR) by speckle tracking. Mean LV volume/mass ratio was 0.34 ± 0.09 mL/g in healthy controls, 0.15 ± 0.06 mL/g in HCM, 0.6 ± 0.2 mL/g in DCM-n, and 0.8 ± 0.3 mL/g in DCM-w patients (P <0.001 for all groups). Resting LV ejection fractions were 63 ± 7, 64 ± 8, 31 ± 8, and 26 ± 8, respectively (P <0.01 vs. controls for DCM groups). In a multivariate analysis, LV volume/mass ratio remained a strong independent predictor of Vp (P <0.001), IVPG (P = 0.009), and UntwR (P <0.001) but not for Ea (P = 0.25).ConclusionLV volume/mass ratio had influences on diastolic function parameters independent of intrinsic diastolic function and filling pressures. It should be considered when assessing patients suspected of LV diastolic dysfunction.",
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T1 - Impact of left ventricular volume/mass ratio on diastolic function

AU - Buakhamsri, Adisai

AU - Popović, Zoran B.

AU - Lin, Jingna

AU - Lim, Pascal

AU - Greenberg, Neil L.

AU - Borowski, Allen G.

AU - Tang, W. H Wilson

AU - Klein, Allan L.

AU - Lever, Harry M.

AU - Desai, Milind Y.

AU - Thomas, James D.

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N2 - Aims: To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls.Methods and resultsWe performed echocardiography in 44 healthy controls, 35 HCM subjects, 29 DCM subjects with narrow QRS complex (DCM-n), and 27 DCM subjects with wide QRS complex (DCM-w). Mitral annulus velocity (Ea) and transmitral E-wave velocity were used to estimate time constant of isovolumic pressure decay (τ). LV flow propagation velocity (Vp) and early intraventricular pressure gradient (IVPG) were derived from colour M-mode of LV inflow. We calculated LV twist and peak untwisting rate (UntwR) by speckle tracking. Mean LV volume/mass ratio was 0.34 ± 0.09 mL/g in healthy controls, 0.15 ± 0.06 mL/g in HCM, 0.6 ± 0.2 mL/g in DCM-n, and 0.8 ± 0.3 mL/g in DCM-w patients (P <0.001 for all groups). Resting LV ejection fractions were 63 ± 7, 64 ± 8, 31 ± 8, and 26 ± 8, respectively (P <0.01 vs. controls for DCM groups). In a multivariate analysis, LV volume/mass ratio remained a strong independent predictor of Vp (P <0.001), IVPG (P = 0.009), and UntwR (P <0.001) but not for Ea (P = 0.25).ConclusionLV volume/mass ratio had influences on diastolic function parameters independent of intrinsic diastolic function and filling pressures. It should be considered when assessing patients suspected of LV diastolic dysfunction.

AB - Aims: To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls.Methods and resultsWe performed echocardiography in 44 healthy controls, 35 HCM subjects, 29 DCM subjects with narrow QRS complex (DCM-n), and 27 DCM subjects with wide QRS complex (DCM-w). Mitral annulus velocity (Ea) and transmitral E-wave velocity were used to estimate time constant of isovolumic pressure decay (τ). LV flow propagation velocity (Vp) and early intraventricular pressure gradient (IVPG) were derived from colour M-mode of LV inflow. We calculated LV twist and peak untwisting rate (UntwR) by speckle tracking. Mean LV volume/mass ratio was 0.34 ± 0.09 mL/g in healthy controls, 0.15 ± 0.06 mL/g in HCM, 0.6 ± 0.2 mL/g in DCM-n, and 0.8 ± 0.3 mL/g in DCM-w patients (P <0.001 for all groups). Resting LV ejection fractions were 63 ± 7, 64 ± 8, 31 ± 8, and 26 ± 8, respectively (P <0.01 vs. controls for DCM groups). In a multivariate analysis, LV volume/mass ratio remained a strong independent predictor of Vp (P <0.001), IVPG (P = 0.009), and UntwR (P <0.001) but not for Ea (P = 0.25).ConclusionLV volume/mass ratio had influences on diastolic function parameters independent of intrinsic diastolic function and filling pressures. It should be considered when assessing patients suspected of LV diastolic dysfunction.

KW - Diastolic function

KW - Dilated cardiomyopathy

KW - Echocardiography

KW - Hypertrophic cardiomyopathy

KW - Left ventricular volume/mass ratio

KW - Ventricular torsion (twist)

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