Impact of iron loading on the activity of isoniazid or ethambutol in the treatment of murine tuberculosis

Nacer Lounis, C. Maslo, C. Truffot-Pernot, J. Grosset, R. J. Boelaert

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To assess the impact of iron loading on the activity of isoniazid and ethambutol in the treatment of murine tuberculosis. DESIGN: Iron-loaded and iron-normal female Balb/C mice infected with 1.5 × 107 colony forming units of Mycobacterium tuberculosis were treated with either isoniazid or ethambutol for 28 days. RESULTS: For both treatments, the outcome was impaired by the iron loading: bactericidal activity of isoniazid was partially but significantly reduced and ethambutol bactericidal activity was totally inhibited. CONCLUSION: The treatment of tuberculosis in patients with iron loading should be longer than for normal patients or should contain an additional drug.

Original languageEnglish (US)
Pages (from-to)575-579
Number of pages5
JournalInternational Journal of Tuberculosis and Lung Disease
Volume7
Issue number6
StatePublished - Jun 1 2003

Keywords

  • Ethambutol
  • Experimental infection
  • Iron
  • Isoniazid
  • Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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