Abstract
OBJECTIVE: To assess the impact of iron loading on the activity of isoniazid and ethambutol in the treatment of murine tuberculosis. DESIGN: Iron-loaded and iron-normal female Balb/C mice infected with 1.5 × 107 colony forming units of Mycobacterium tuberculosis were treated with either isoniazid or ethambutol for 28 days. RESULTS: For both treatments, the outcome was impaired by the iron loading: bactericidal activity of isoniazid was partially but significantly reduced and ethambutol bactericidal activity was totally inhibited. CONCLUSION: The treatment of tuberculosis in patients with iron loading should be longer than for normal patients or should contain an additional drug.
Original language | English (US) |
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Pages (from-to) | 575-579 |
Number of pages | 5 |
Journal | International Journal of Tuberculosis and Lung Disease |
Volume | 7 |
Issue number | 6 |
State | Published - Jun 1 2003 |
Externally published | Yes |
Keywords
- Ethambutol
- Experimental infection
- Iron
- Isoniazid
- Mycobacterium tuberculosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Infectious Diseases