Impact of introduction of the haemophilus influenzae type b conjugate vaccine into childhood immunization on meningitis in Bangladeshi infants

Nadira K. Sultana, Samir K. Saha, Hassan M. Al-Emran, Joyanta K. Modak, M. A.Yushuf Sharker, Shams El-Arifeen, Adam L. Cohen, Abdullah H. Baqui, Stephen P. Luby

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Some Asian countries have been reluctant to adopt Haemophilus influenzae type b (Hib) conjugate vaccination because of uncertainty over disease burden. We assessed the impact of introduction of Hib conjugate vaccine into the Expanded Program on Immunization in Bangladesh on purulent and laboratory-confirmed H influenzae meningitis. Study design: Within a well-defined catchment area around 2 surveillance hospitals in Dhaka, Bangladesh, we compared the incidence of Hib meningitis confirmed by culture, latex agglutination, and polymerase chain reaction assay among infants 1 year before and 1 year after introduction of Hib conjugate vaccine. We adjusted the incidence rate for the proportion of children who sought care at the surveillance hospitals. Results: Among infants, the incidence of confirmed Hib meningitis decreased from 92-16 cases per 100 000 within 1 year of vaccine introduction (vaccine preventable incidence = 76; 95% CI 18, 135 per 100 000). The incidence of purulent meningitis decreased from 1659-1159 per 100 000 (vaccine preventable incidence = 500; 95% CI: 203, 799 per 100 000). During the same time period, there was no significant difference in the incidence of meningitis due to Streptococcus pneumoniae. Conclusions: Introduction of conjugate Hib conjugate vaccine into Bangladesh Expanded Program on Immunization markedly reduced the burden of Hib and purulent meningitis.

Original languageEnglish (US)
Pages (from-to)S73-S78
JournalJournal of Pediatrics
Volume163
Issue number1 SUPPL
DOIs
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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