TY - JOUR
T1 - Impact of intrapartum antibiotics on the care and evaluation of the neonate
AU - Balter, Sharon
AU - Zell, Elizabeth R.
AU - O'brien, Katherine L.
AU - Roome, Aaron
AU - Noga, Heather
AU - Thayu, Meena
AU - Schuchat, Anne
PY - 2003/10
Y1 - 2003/10
N2 - Background. Numerousstudies evaluating the efficacy of conjugate pneumococcal vaccines are being conducted or planned throughout the world. Some of these studies are evaluating the effect of vaccine on nasopharyngeal (NP) carriage. Methods. The World Health Organization established a Working Group comprised of representatives from these trials and other NP colonization experts to establish core, standardized methods for the study of pneumococcal NP colonization that could be used in these trials. The intent was to reduce or eliminate variability in key methods which themselves could contribute to variability of observed pneumococcal NP colonization. In this way variability of vaccine effects between trials on NP colonization could more easily be analyzed for population or vaccine differences without the confounding effect caused by differences in study methodology. Results. This paper presents the evidence base supporting the need for standardized NP colonization study methods, the methods themselves (Core Consensus Methods), including collection techniques, culture media, equipment, serotyping, storage of specimens and transport of isolates agreed on by the Working Group as well as a discussion of research priorities. Conclusions. The Core Consensus Methods provide a common methodology to conduct pneumococcal NP colonization studies with minimum interstudy method variability. The intention is to allow more meaningful comparisons of study results from conjugate pneumococcal vaccine trials.
AB - Background. Numerousstudies evaluating the efficacy of conjugate pneumococcal vaccines are being conducted or planned throughout the world. Some of these studies are evaluating the effect of vaccine on nasopharyngeal (NP) carriage. Methods. The World Health Organization established a Working Group comprised of representatives from these trials and other NP colonization experts to establish core, standardized methods for the study of pneumococcal NP colonization that could be used in these trials. The intent was to reduce or eliminate variability in key methods which themselves could contribute to variability of observed pneumococcal NP colonization. In this way variability of vaccine effects between trials on NP colonization could more easily be analyzed for population or vaccine differences without the confounding effect caused by differences in study methodology. Results. This paper presents the evidence base supporting the need for standardized NP colonization study methods, the methods themselves (Core Consensus Methods), including collection techniques, culture media, equipment, serotyping, storage of specimens and transport of isolates agreed on by the Working Group as well as a discussion of research priorities. Conclusions. The Core Consensus Methods provide a common methodology to conduct pneumococcal NP colonization studies with minimum interstudy method variability. The intention is to allow more meaningful comparisons of study results from conjugate pneumococcal vaccine trials.
KW - Group BStreptococcus
KW - Intrapartum antibiotics
KW - Neonatal management
UR - http://www.scopus.com/inward/record.url?scp=0142025410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0142025410&partnerID=8YFLogxK
U2 - 10.1097/01.inf.0000090920.22425.dc
DO - 10.1097/01.inf.0000090920.22425.dc
M3 - Article
C2 - 14551483
AN - SCOPUS:0142025410
SN - 0891-3668
VL - 22
SP - 853
EP - 857
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 10
ER -