Impact of intrafraction and residual interfraction effect on prostate proton pencil beam scanning

Shikui Tang, Curtiland Deville, Zelig Tochner, Kang-Hsin Wang, James McDonough, Neha Vapiwala, Stefan Both

Research output: Contribution to journalArticle

Abstract

Purpose To quantitatively evaluate the impact of interplay effect and plan robustness associated with intrafraction and residual interfraction prostate motion for pencil beam scanning proton therapy.

Methods and Materials Ten prostate cancer patients with weekly verification CTs underwent pencil beam scanning with the bilateral single-field uniform dose (SFUD) modality. A typical field had 10-15 energy layers and 500-1000 spots. According to their treatment logs, each layer delivery time was

Results The clinical target volume (CTV) coverage was degraded because of both effects. The CTV D99 (percentage dose to 99% of the CTV) varied up to 10% relative to the initial plan in individual fractions. However, over the entire course of treatment the total dose degradation of D99 was 2%-3%, with a standard deviation of

Conclusions Both intrafraction and residual interfraction prostate motion degrade CTV coverage within a clinically acceptable level. One-field-per-day SFUD delivered twice is as robust as the bilateral SFUD plan treated daily over the course of treatment.

Original languageEnglish (US)
Pages (from-to)1186-1194
Number of pages9
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume90
Issue number5
DOIs
StatePublished - Dec 1 2014

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pencil beams
proton beams
Protons
Prostate
dosage
scanning
Proton Therapy
Prostatic Neoplasms
Therapeutics
standard deviation
therapy
delivery
cancer
degradation
protons

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research
  • Medicine(all)

Cite this

Impact of intrafraction and residual interfraction effect on prostate proton pencil beam scanning. / Tang, Shikui; Deville, Curtiland; Tochner, Zelig; Wang, Kang-Hsin; McDonough, James; Vapiwala, Neha; Both, Stefan.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 90, No. 5, 01.12.2014, p. 1186-1194.

Research output: Contribution to journalArticle

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AU - Deville, Curtiland

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AU - McDonough, James

AU - Vapiwala, Neha

AU - Both, Stefan

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