Impact of interventions to reduce Alzheimer's disease pathology on the prevalence of dementia in the oldest-old

Ron Brookmeyer, Claudia H. Kawas, Nada Abdallah, Annlia Paganini-Hill, Ronald C. Kim, María M. Corrada

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Introduction The number of persons aged >90 years will grow significantly in coming decades. This group has the highest rates of dementia, most commonly Alzheimer's disease (AD). Methods Using The 90+ Study, we developed a statistical model for dementia risk based on brain pathologies. Intervention scenarios which reduce or eliminate AD pathology were considered, and the numbers of dementia cases among the U.S. oldest-old that could be prevented were estimated. Results The U.S. dementia prevalence among the oldest-old will increase from 1.35 million in 2015 to 4.72 million in 2050. If interventions eliminate AD pathology, dementia prevalence would be reduced by approximately 50%, averting nearly 2.4 million cases in 2050. However, large numbers of dementia cases would still remain. Discussion Reducing AD pathology would significantly decrease the public health burden of dementia. However, other interventions are needed to address the burden associated with other dementing pathologies prevalent in the oldest-old.

Original languageEnglish (US)
Pages (from-to)225-232
Number of pages8
JournalAlzheimer's and Dementia
Issue number3
StatePublished - Mar 1 2016


  • Alzheimer's disease
  • Dementia
  • Intervention
  • Oldest-old
  • Pathology
  • Prediction
  • Prevalence
  • Prevention

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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