Impact of implantable cardioverter defibrillators on survival and recurrent hospitalization in advanced heart failure

Saman Nazarian, William H. Maisel, J. Shawn Miles, Sui Tsang, Lynne W. Stevenson, William G. Stevenson

Research output: Contribution to journalArticle

Abstract

Background: Although implantable cardioverter defibrillators (ICDs) are increasingly used in advanced (class III/IV) heart failure, their benefits may be limited by death from pump failure and data are limited. The aim of this study was to assess the impact of QRS duration and disease etiology on survival and rehospitalization in advanced heart failure patients with ICDs. Methods: A retrospective study of 438 patients with heart failure (age 56 ± 15, ejection fraction 29 ± 15, 76% class III/IV) discharged between 1996 and 2000 was performed. Results: An ICD was placed in 94 of the 438 patients for nonsustained (51.1%) or sustained (24.4%) ventricular arrhythmia, syncope (16.0%), or prophylaxis (8.5%). Patients with ICDs had a lower mean baseline ejection fraction (25% vs 30%, P = .007) but a trend toward fewer class IV symptoms (33% vs 44%, P = .164). Patients with ICDs had better survival (RR 0.48, P = .001) but increased rehospitalization (RR 1.41, P = .031). In both the ischemic and nonischemic subgroups, survival was superior in patients with ICDs (RR 0.38, P = .003 and RR 0.54, P = .042). Patients with QRS

Original languageEnglish (US)
Pages (from-to)955-960
Number of pages6
JournalAmerican Heart Journal
Volume150
Issue number5
DOIs
StatePublished - Nov 2005

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Implantable Defibrillators
Hospitalization
Heart Failure
Survival
Syncope
Cardiac Arrhythmias
Retrospective Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nazarian, S., Maisel, W. H., Miles, J. S., Tsang, S., Stevenson, L. W., & Stevenson, W. G. (2005). Impact of implantable cardioverter defibrillators on survival and recurrent hospitalization in advanced heart failure. American Heart Journal, 150(5), 955-960. https://doi.org/10.1016/j.ahj.2005.01.012

Impact of implantable cardioverter defibrillators on survival and recurrent hospitalization in advanced heart failure. / Nazarian, Saman; Maisel, William H.; Miles, J. Shawn; Tsang, Sui; Stevenson, Lynne W.; Stevenson, William G.

In: American Heart Journal, Vol. 150, No. 5, 11.2005, p. 955-960.

Research output: Contribution to journalArticle

Nazarian, Saman ; Maisel, William H. ; Miles, J. Shawn ; Tsang, Sui ; Stevenson, Lynne W. ; Stevenson, William G. / Impact of implantable cardioverter defibrillators on survival and recurrent hospitalization in advanced heart failure. In: American Heart Journal. 2005 ; Vol. 150, No. 5. pp. 955-960.
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