TY - JOUR
T1 - Impact of human papillomavirus on oropharyngeal cancer biology and response to therapy. Implications for treatment
AU - Bonilla-Velez, Juliana
AU - Mroz, Edmund A.
AU - Hammon, Rebecca J.
AU - Rocco, James W.
N1 - Funding Information:
Funding Sources and Support: Flight Attendant Medical Research Institute ; NIH NIDCR R01 DE022087 ; NCI R21 CA119591 ; NIDCD T32 DC000020 ; 2012 AAO-HNSF Resident Research Award; Principles and Practice of Clinical Research and Latin American Initiative program, Harvard Medical School.
PY - 2013/8
Y1 - 2013/8
N2 - Oropharyngeal squamous cell carcinoma (OPSCC) originating from human papillomavirus infection has emerged as a new entity in head and neck cancer, defining a subset of patients with distinct carcinogenesis, risk factor profiles, and clinical presentation that show markedly improved survival than patients with classic OPSCC. De-escalation of therapy and identification of relevant biomarkers to aid in patient selection are actively being investigated. This review addresses the implications of these findings in clinical care.
AB - Oropharyngeal squamous cell carcinoma (OPSCC) originating from human papillomavirus infection has emerged as a new entity in head and neck cancer, defining a subset of patients with distinct carcinogenesis, risk factor profiles, and clinical presentation that show markedly improved survival than patients with classic OPSCC. De-escalation of therapy and identification of relevant biomarkers to aid in patient selection are actively being investigated. This review addresses the implications of these findings in clinical care.
KW - Clinical implications
KW - HPV-positive oropharyngeal cancer
KW - Treatment implications
UR - http://www.scopus.com/inward/record.url?scp=84881028404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881028404&partnerID=8YFLogxK
U2 - 10.1016/j.otc.2013.04.009
DO - 10.1016/j.otc.2013.04.009
M3 - Review article
C2 - 23910468
AN - SCOPUS:84881028404
SN - 0030-6665
VL - 46
SP - 521
EP - 543
JO - Otolaryngologic Clinics of North America
JF - Otolaryngologic Clinics of North America
IS - 4
ER -