Impact of human papillomavirus on oropharyngeal cancer biology and response to therapy. Implications for treatment

Juliana Bonilla-Velez, Edmund A. Mroz, Rebecca J. Hammon, James W. Rocco

Research output: Contribution to journalReview articlepeer-review

Abstract

Oropharyngeal squamous cell carcinoma (OPSCC) originating from human papillomavirus infection has emerged as a new entity in head and neck cancer, defining a subset of patients with distinct carcinogenesis, risk factor profiles, and clinical presentation that show markedly improved survival than patients with classic OPSCC. De-escalation of therapy and identification of relevant biomarkers to aid in patient selection are actively being investigated. This review addresses the implications of these findings in clinical care.

Original languageEnglish (US)
Pages (from-to)521-543
Number of pages23
JournalOtolaryngologic Clinics of North America
Volume46
Issue number4
DOIs
StatePublished - Aug 2013

Keywords

  • Clinical implications
  • HPV-positive oropharyngeal cancer
  • Treatment implications

ASJC Scopus subject areas

  • Otorhinolaryngology

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