TY - JOUR
T1 - Impact of host and virus genome variability on HCV replication and response to interferon
AU - Schweitzer, Cameron J.
AU - Liang, T. Jake
PY - 2013
Y1 - 2013
N2 - Since the discovery of hepatitis C virus (HCV), treatment has proven difficult and the regimen of pegylated interferon-α and ribavirin is only effective for half of patients. Evidence suggests that host and viral genome variations play a role in either viral clearance or persistence. Powerful genomic technologies have made it possible to study genome-wide associations with treatment response, which yielded critical genetic polymorphisms that predict treatment response. This has important implications for treatment of HCV infection and opened the door to the possibility of genetic marker-guided treatment (personalized medicine). This review will focus on the recent advances in understanding host and viral genetic variations with regards to treatment and the importance for future therapeutic intervention.
AB - Since the discovery of hepatitis C virus (HCV), treatment has proven difficult and the regimen of pegylated interferon-α and ribavirin is only effective for half of patients. Evidence suggests that host and viral genome variations play a role in either viral clearance or persistence. Powerful genomic technologies have made it possible to study genome-wide associations with treatment response, which yielded critical genetic polymorphisms that predict treatment response. This has important implications for treatment of HCV infection and opened the door to the possibility of genetic marker-guided treatment (personalized medicine). This review will focus on the recent advances in understanding host and viral genetic variations with regards to treatment and the importance for future therapeutic intervention.
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U2 - 10.1016/j.coviro.2013.06.005
DO - 10.1016/j.coviro.2013.06.005
M3 - Article
C2 - 23835049
AN - SCOPUS:84885952071
SN - 1879-6257
VL - 3
SP - 501
EP - 507
JO - Current Opinion in Virology
JF - Current Opinion in Virology
IS - 5
ER -