Impact of host and virus genome variability on HCV replication and response to interferon

Cameron J. Schweitzer, T. Jake Liang

Research output: Contribution to journalArticle

Abstract

Since the discovery of hepatitis C virus (HCV), treatment has proven difficult and the regimen of pegylated interferon-α and ribavirin is only effective for half of patients. Evidence suggests that host and viral genome variations play a role in either viral clearance or persistence. Powerful genomic technologies have made it possible to study genome-wide associations with treatment response, which yielded critical genetic polymorphisms that predict treatment response. This has important implications for treatment of HCV infection and opened the door to the possibility of genetic marker-guided treatment (personalized medicine). This review will focus on the recent advances in understanding host and viral genetic variations with regards to treatment and the importance for future therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)501-507
Number of pages7
JournalCurrent Opinion in Virology
Volume3
Issue number5
DOIs
StatePublished - 2013
Externally publishedYes

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Virus Replication
Hepacivirus
Interferons
Genome
Viruses
Therapeutics
Precision Medicine
Ribavirin
Viral Genome
Genome-Wide Association Study
Genetic Polymorphisms
Virus Diseases
Genetic Markers
Technology

ASJC Scopus subject areas

  • Virology

Cite this

Impact of host and virus genome variability on HCV replication and response to interferon. / Schweitzer, Cameron J.; Liang, T. Jake.

In: Current Opinion in Virology, Vol. 3, No. 5, 2013, p. 501-507.

Research output: Contribution to journalArticle

Schweitzer, Cameron J. ; Liang, T. Jake. / Impact of host and virus genome variability on HCV replication and response to interferon. In: Current Opinion in Virology. 2013 ; Vol. 3, No. 5. pp. 501-507.
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