Impact of HIV on lung tumorigenesis in an animal model

Shigeru Kawabata, Alonso Heredia, Joell Gills, Robert R. Redfield, Phillip A. Dennis, Joseph Bryant

Research output: Contribution to journalArticlepeer-review

Abstract

Many HIV patients on antiretroviral therapy have controlled viremia and restored (albeit partially) immunity. Yet, they have high rates of lung cancer, even after controlling for smoking. We tested the hypothesis that HIV proteins accelerate development/progression of lung cancer in an immunocompetent HIV transgenic mouse model. The expression of HIV proteins did not enhance lung tumorigenesis caused by two different tobacco carcinogens, suggesting that incompletely restored immunity and/or inflammation, which persist(s) in most HIV patients despite controlled viremia, underlie(s) excess risk of lung cancer. Adjuvant therapies that restore immunity and lower inflammation may decrease lung cancer mortality in HIV patients.

Original languageEnglish (US)
Pages (from-to)633-635
Number of pages3
JournalAIDS
Volume29
Issue number5
DOIs
StatePublished - Mar 13 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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