Impact of Haemophilus influenzae Type b Conjugate Vaccines (HibCV) on Nasopharyngeal Carriage in HIV Infected Children and Their Parents from West Bengal, India

Bikas K. Arya, Sangeeta Das Bhattacharya, Catherine Sutcliffe, Swapan Kumar Niyogi, Subhasish Bhattacharyya, Sunil Hemram, William J Moss, Samiran Panda, Ranjan Saurav Das, Sutapa Mandal, Dennis Robert, Pampa Ray

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: In addition to reducing Haemophilus influenzae type b (Hib) disease in vaccinated individuals, the Hib conjugate vaccine (HibCV) has indirect effects; it reduces Hib disease in unvaccinated individuals by decreasing carriage. HIV infected children are at increased risk for Hib disease and live in families where multiple members may have HIV. OBJECTIVE: To look at the impact of 2 doses of the HibCV on nasopharyngeal carriage of Hib in HIV infected Indian children (2-15 years) and the indirect impact on carriage in their parents. METHODS: This prospective cohort study was conducted in HIV infected and uninfected families. Nasopharyngeal swabs were collected from children and parents before and after vaccination. HIV infected children ages 2-15 years got two doses of HibCV and were followed up for 20 months. Uninfected children age 2-5 years got 1 dose of HibCV as catch-up. RESULTS: 123 HIV infected and 44 HIV uninfected children participated. Baseline colonization in HIV infected children was13.8% and dropped to 1.8% (p=0.002) at 20 months. Baseline carriage in HIV uninfected children was 4.5%, and dropped to 2.3% after vaccination (p=0.3). HIV infected parents had 12.3 times increased risk of Hib carriage if their child was colonized (p=0.04) and 9.3 times increased risk if their child had persistent colonization post vaccine (p=0.05). No parent of HIV uninfected children had Hib colonization at any point. Pneumococcal colonization was associated with increased Hib colonization. CONCLUSION: Making the HibCV available to HIV infected children could interrupt Hib carriage in high risk families.

Original languageEnglish (US)
JournalPediatric Infectious Disease Journal
DOIs
StateAccepted/In press - Jun 7 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

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