Impact of donor-specific antibodies in reconstructive transplantation.

Angelo A. Leto Barone, Zhao Li Sun, Robert A. Montgomery, W P Andrew Lee, Gerald Brandacher

Research output: Contribution to journalArticle

Abstract

For many devastating injuries and tissue defects where conventional reconstruction is not possible, reconstructive transplantation such as hand and face transplantation has become a viable alternative. This novel approach allows for improved restoration of appearance, anatomy and function not feasible by other available treatment options. However, clinical management of these injuries prior to transplantation frequently requires multiple blood transfusion or skin grafts resulting in the formation of alloantibodies (anti-HLA IgG Abs) and a high degree of sensitization. The role of donor-specific antibodies (DSA) and mechanisms of antibody-mediated rejection (AMR) in reconstructive transplantation are still largely unknown. Thus there is an imminent need to develop a better understanding of the mechanisms related to DSA and AMR after reconstructive transplantation. In this review, we will define the role of DSA and mechanisms of AMR in reconstructive transplantation and compare them to established measures and treatment concepts in solid organ transplantation.

Original languageEnglish (US)
Pages (from-to)835-844
Number of pages10
JournalExpert Review of Clinical Immunology
Volume9
Issue number9
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

Transplantation
Antibodies
Hand Transplantation
Facial Transplantation
Isoantibodies
Wounds and Injuries
Organ Transplantation
Blood Transfusion
Anatomy
Transplants
Skin
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Impact of donor-specific antibodies in reconstructive transplantation. / Leto Barone, Angelo A.; Sun, Zhao Li; Montgomery, Robert A.; Lee, W P Andrew; Brandacher, Gerald.

In: Expert Review of Clinical Immunology, Vol. 9, No. 9, 09.2013, p. 835-844.

Research output: Contribution to journalArticle

Leto Barone, Angelo A. ; Sun, Zhao Li ; Montgomery, Robert A. ; Lee, W P Andrew ; Brandacher, Gerald. / Impact of donor-specific antibodies in reconstructive transplantation. In: Expert Review of Clinical Immunology. 2013 ; Vol. 9, No. 9. pp. 835-844.
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