Impact of donor hepatitis C virus infection status on death and need for liver transplant in hepatitis C virus-positive kidney transplant recipients

Lauren M. Kucirka, Thomas G. Peters, Dorry Segev

Research output: Contribution to journalArticle

Abstract

Background: Only 29% of deceased donor kidney recipients with hepatitis C virus (HCV) receive HCV-positive (HCV+) kidneys. These kidneys are discarded 2.5 times more often than their HCV-negative (HCV-) counterparts, possibly due to the sense that an HCV+ kidney may adversely affect recipient liver function. The goals of this study were to characterize liver disease in HCV+ kidney recipients and compare rates of liver-related outcomes by kidney donor HCV status. Study Design: Observational cohort study. Setting & Participants: 6,250 patients with HCV who had a kidney transplant in 1995-2008 as captured in the United Network for Organ Sharing (UNOS) database. Liver-related outcomes were assessed by cross-linking with the liver waitlist and transplant data sets. Predictor: HCV status of transplanted kidney. Outcomes: Joining the liver waitlist, receiving a liver transplant, death. Measurements: Time to event. Results: Only 63 (1%) of HCV+ kidney recipients eventually joined the liver waitlist during the 13-year study period. Those who received HCV+ kidneys had a 2.6-fold higher hazard of joining the liver list (P <0.001); however, the absolute difference in rate of listing between recipients of HCV- and HCV+ kidneys was

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalAmerican Journal of Kidney Diseases
Volume60
Issue number1
DOIs
StatePublished - Jul 2012

Fingerprint

Virus Diseases
Hepacivirus
Tissue Donors
Transplants
Kidney
Liver
Transplant Recipients
Observational Studies
Liver Diseases
Cohort Studies

Keywords

  • competing risks
  • Hepatitis C
  • kidney transplant
  • liver transplant

ASJC Scopus subject areas

  • Nephrology

Cite this

Impact of donor hepatitis C virus infection status on death and need for liver transplant in hepatitis C virus-positive kidney transplant recipients. / Kucirka, Lauren M.; Peters, Thomas G.; Segev, Dorry.

In: American Journal of Kidney Diseases, Vol. 60, No. 1, 07.2012, p. 112-120.

Research output: Contribution to journalArticle

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abstract = "Background: Only 29{\%} of deceased donor kidney recipients with hepatitis C virus (HCV) receive HCV-positive (HCV+) kidneys. These kidneys are discarded 2.5 times more often than their HCV-negative (HCV-) counterparts, possibly due to the sense that an HCV+ kidney may adversely affect recipient liver function. The goals of this study were to characterize liver disease in HCV+ kidney recipients and compare rates of liver-related outcomes by kidney donor HCV status. Study Design: Observational cohort study. Setting & Participants: 6,250 patients with HCV who had a kidney transplant in 1995-2008 as captured in the United Network for Organ Sharing (UNOS) database. Liver-related outcomes were assessed by cross-linking with the liver waitlist and transplant data sets. Predictor: HCV status of transplanted kidney. Outcomes: Joining the liver waitlist, receiving a liver transplant, death. Measurements: Time to event. Results: Only 63 (1{\%}) of HCV+ kidney recipients eventually joined the liver waitlist during the 13-year study period. Those who received HCV+ kidneys had a 2.6-fold higher hazard of joining the liver list (P <0.001); however, the absolute difference in rate of listing between recipients of HCV- and HCV+ kidneys was",
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