Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer

Jane Bayani, Miltiadis Paliouras, Chris Planque, Shannon J.C. Shan, Cassandra Graham, Jeremy A. Squire, Eleftherios P. Diamandis

Research output: Contribution to journalArticle

Abstract

The tissue kallikrein (KLK) genes are a new source for biomarkers in ovarian cancer. However, there has been no systematic analysis of copy number and structural rearrangements related to their protein expression. Chromosomal rearrangements and copy number changes of the KLK region were studied by FISH with protein levels measured by ELISA. Ovarian cancer and cell lines revealed the KLK region was subject to copy number imbalances or involved in unbalanced translocations and were associated with increased protein expression of KLKs 5, 6, 7, 8, 9, 10 and 11. In this initial study, we introduce the potential for long-range chromosomal effects and copy number as a mechanism for the previously reported aberrant expression of many KLK genes in ovarian cancers.

Original languageEnglish (US)
Pages (from-to)250-260
Number of pages11
JournalMolecular oncology
Volume2
Issue number3
DOIs
StatePublished - Oct 1 2008

Keywords

  • Chromosomal rearrangements
  • Human kallikreins
  • Ovarian cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Oncology
  • Cancer Research

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    Bayani, J., Paliouras, M., Planque, C., Shan, S. J. C., Graham, C., Squire, J. A., & Diamandis, E. P. (2008). Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer. Molecular oncology, 2(3), 250-260. https://doi.org/10.1016/j.molonc.2008.07.001