TY - JOUR
T1 - Impact of complications on long-term survival after resection of intrahepatic cholangiocarcinoma
AU - Spolverato, Gaya
AU - Yakoob, Mohammad Y.
AU - Kim, Yuhree
AU - Alexandrescu, Sorin
AU - Marques, Hugo P.
AU - Lamelas, Jorge
AU - Aldrighetti, Luca
AU - Gamblin, T. Clark
AU - Maithel, Shishir K.
AU - Pulitano, Carlo
AU - Bauer, Todd W.
AU - Shen, Feng
AU - Poultsides, George A.
AU - Marsh, J. Wallis
AU - Pawlik, Timothy M.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - BACKGROUND The impact of postoperative complications on the long-term outcomes of patients undergoing surgery for cancer is unclear. The objective of the current study was to define the incidence of complications among patients undergoing surgery for intrahepatic cholangiocarcinoma (ICC) and identify the association between morbidity and long-term outcomes. METHODS A total of 583 patients undergoing surgery with curative intent for ICC between 1990 and 2013 at 1 of 12 participating institutions were identified. The association between the occurrence and severity of postoperative complications on long-term survival was analyzed. RESULTS The median age of the patients was 59.9 years and the majority of patients were Male (52.3%). A total of 91 patients (15.6%) and 153 patients (26.2%) developed a major and minor postoperative complication, respectively; 18 patients (3.5%) died within 90 days of surgery. Median, 1-year, 3-year, and 5-year recurrence-free survival were 10.0 months, 43.3%, 16.7%, and 11.1%, respectively. Postoperative complications (hazard ratio [HR], 1.37, 95% confidence interval [95% CI], 1.08-1.73 [P=.01]) and severity of complications (major vs none: HR, 1.55; 95% CI, 1.14-2.11 [P=.01]; minor vs none: HR, 1.30; 95% CI, 0.99-1.70 [P=.06]) independently predicted shorter recurrence-free survival. Median, 1-year, 3-year, and 5-year overall survival was 27.8 months, 76.8%, 39.0%, and 23.4%, respectively. Postoperative complications (HR, 1.64; 95% CI, 1.30-2.08 [P
AB - BACKGROUND The impact of postoperative complications on the long-term outcomes of patients undergoing surgery for cancer is unclear. The objective of the current study was to define the incidence of complications among patients undergoing surgery for intrahepatic cholangiocarcinoma (ICC) and identify the association between morbidity and long-term outcomes. METHODS A total of 583 patients undergoing surgery with curative intent for ICC between 1990 and 2013 at 1 of 12 participating institutions were identified. The association between the occurrence and severity of postoperative complications on long-term survival was analyzed. RESULTS The median age of the patients was 59.9 years and the majority of patients were Male (52.3%). A total of 91 patients (15.6%) and 153 patients (26.2%) developed a major and minor postoperative complication, respectively; 18 patients (3.5%) died within 90 days of surgery. Median, 1-year, 3-year, and 5-year recurrence-free survival were 10.0 months, 43.3%, 16.7%, and 11.1%, respectively. Postoperative complications (hazard ratio [HR], 1.37, 95% confidence interval [95% CI], 1.08-1.73 [P=.01]) and severity of complications (major vs none: HR, 1.55; 95% CI, 1.14-2.11 [P=.01]; minor vs none: HR, 1.30; 95% CI, 0.99-1.70 [P=.06]) independently predicted shorter recurrence-free survival. Median, 1-year, 3-year, and 5-year overall survival was 27.8 months, 76.8%, 39.0%, and 23.4%, respectively. Postoperative complications (HR, 1.64; 95% CI, 1.30-2.08 [P
KW - complications
KW - intrahepatic cholangiocarcinoma
KW - recurrence
KW - survival
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U2 - 10.1002/cncr.29419
DO - 10.1002/cncr.29419
M3 - Article
C2 - 25903409
AN - SCOPUS:84938737957
VL - 121
SP - 2730
EP - 2739
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 16
ER -