Impact of complications on long-term survival after resection of intrahepatic cholangiocarcinoma

Gaya Spolverato, Mohammad Y. Yakoob, Yuhree Kim, Sorin Alexandrescu, Hugo P. Marques, Jorge Lamelas, Luca Aldrighetti, T. Clark Gamblin, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, J. Wallis Marsh, Timothy M. Pawlik

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


BACKGROUND The impact of postoperative complications on the long-term outcomes of patients undergoing surgery for cancer is unclear. The objective of the current study was to define the incidence of complications among patients undergoing surgery for intrahepatic cholangiocarcinoma (ICC) and identify the association between morbidity and long-term outcomes. METHODS A total of 583 patients undergoing surgery with curative intent for ICC between 1990 and 2013 at 1 of 12 participating institutions were identified. The association between the occurrence and severity of postoperative complications on long-term survival was analyzed. RESULTS The median age of the patients was 59.9 years and the majority of patients were Male (52.3%). A total of 91 patients (15.6%) and 153 patients (26.2%) developed a major and minor postoperative complication, respectively; 18 patients (3.5%) died within 90 days of surgery. Median, 1-year, 3-year, and 5-year recurrence-free survival were 10.0 months, 43.3%, 16.7%, and 11.1%, respectively. Postoperative complications (hazard ratio [HR], 1.37, 95% confidence interval [95% CI], 1.08-1.73 [P=.01]) and severity of complications (major vs none: HR, 1.55; 95% CI, 1.14-2.11 [P=.01]; minor vs none: HR, 1.30; 95% CI, 0.99-1.70 [P=.06]) independently predicted shorter recurrence-free survival. Median, 1-year, 3-year, and 5-year overall survival was 27.8 months, 76.8%, 39.0%, and 23.4%, respectively. Postoperative complications (HR, 1.64; 95% CI, 1.30-2.08 [P

Original languageEnglish (US)
Pages (from-to)2730-2739
Number of pages10
Issue number16
StatePublished - Aug 1 2015


  • complications
  • intrahepatic cholangiocarcinoma
  • recurrence
  • survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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