IMPACT OF B SUBUNIT KILLED WHOLE-CELL AND KILLED WHOLE-CELL-ONLY ORAL VACCINES AGAINST CHOLERA UPON TREATED DIARRHOEAL ILLNESS AND MORTALITY IN AN AREA ENDEMIC FOR CHOLERA

JohnD Clemens, JeffreyR Harris, M. R. Khan, Mohammad Ali, M. Yunus, M. U. Khan, Ann Mari Svennerholm, David Allen Sack, J. Chakraborty, BonitaF Stanton, F. Ahmed, BradfordA Kay, M. R. Rao, Jan Holmgren

Research output: Contribution to journalArticle

Abstract

The impact of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind trial in rural Bangladesh. 62 285 children aged 2-15 years and women aged over 15 ingested three doses of one of the vaccines or placebo. During the first year of follow-up there was a 26% reduction of all visits for treatment of diarrhoea in the BS-WC group and a 22% reduction in the WC group. The reduction of all admissions for fatal or severely dehydrating diarrhoea was 48% in the BS-WC group and 33% in the WC group. Overall mortality rates were 26% lower in the BS-WC group and 23% lower in the WC group during the first year, and reductions of mortality were observed only in women vaccinated at ages over 15 years. However, no differences in cumulative mortality were evident at the end of the second year of surveillance.

Original languageEnglish (US)
Pages (from-to)1375-1379
Number of pages5
JournalThe Lancet
Volume331
Issue number8599
DOIs
Publication statusPublished - Jun 18 1988

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ASJC Scopus subject areas

  • Medicine(all)

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