Abstract
Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.
Original language | English (US) |
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Pages (from-to) | 1319-1322 |
Number of pages | 4 |
Journal | AIDS |
Volume | 26 |
Issue number | 10 |
DOIs | |
State | Published - Jun 19 2012 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases