Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin

Jessica Prodger, Ronald H Gray, Godfrey Kigozi, Fred Nalugoda, Ronald Galiwango, Kighoma Nehemiah, Moses Kakanga, Taha Hirbod, Maria J. Wawer, Nelson Sewankambo, David Serwadda, Rupert Kaul

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalAIDS
Volume26
Issue number10
DOIs
StatePublished - Jun 19 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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