Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin

Jessica L. Prodger; Ronald Gray; Godfrey Kigozi; Fred Nalugoda; Ronald Galiwango; Kighoma Nehemiah; Moses Kakanga; Taha Hirbod; Maria J. Wawer; Nelson Sewankambo; David Serwadda; Rupert Kaul

doi:10.1097/QAD.0b013e328354675c

Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin

Jessica L. Prodger, Ronald Gray, Godfrey Kigozi, Fred Nalugoda, Ronald Galiwango, Kighoma Nehemiah, Moses Kakanga, Taha Hirbod, Maria J. Wawer, Nelson Sewankambo, David Serwadda, Rupert Kaul

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.

Original language	English (US)
Pages (from-to)	1319-1322
Number of pages	4
Journal	AIDS
Volume	26
Issue number	10
DOIs	https://doi.org/10.1097/QAD.0b013e328354675c
State	Published - Jun 19 2012

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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abstract = "Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.",

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AU - Prodger, Jessica L.

AU - Gray, Ronald

AU - Kigozi, Godfrey

AU - Nalugoda, Fred

AU - Galiwango, Ronald

AU - Nehemiah, Kighoma

AU - Kakanga, Moses

AU - Hirbod, Taha

AU - Wawer, Maria J.

AU - Sewankambo, Nelson

AU - Serwadda, David

AU - Kaul, Rupert

PY - 2012/6/19

Y1 - 2012/6/19

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AB - Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.

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Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin

Abstract

ASJC Scopus subject areas

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