Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin

Jessica L. Prodger, Ronald Gray, Godfrey Kigozi, Fred Nalugoda, Ronald Galiwango, Kighoma Nehemiah, Moses Kakanga, Taha Hirbod, Maria J. Wawer, Nelson Sewankambo, David Serwadda, Rupert Kaul

Research output: Contribution to journalArticle

Abstract

Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalAIDS
Volume26
Issue number10
DOIs
StatePublished - Jun 19 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    Prodger, J. L., Gray, R., Kigozi, G., Nalugoda, F., Galiwango, R., Nehemiah, K., Kakanga, M., Hirbod, T., Wawer, M. J., Sewankambo, N., Serwadda, D., & Kaul, R. (2012). Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin. AIDS, 26(10), 1319-1322. https://doi.org/10.1097/QAD.0b013e328354675c