Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

Chaojie Yang; Brian Hallmark; Jin Choul Chai; Timothy D. O’Connor; Lindsay M. Reynolds; Alexis C. Wood; Michael Seeds; Yii Der Ida Chen; Lyn M. Steffen; Michael Y. Tsai; Robert C. Kaplan; Martha L. Daviglus; Lawrence J. Mandarino; Amanda M. Fretts; Rozenn N. Lemaitre; Dawn K. Coletta; Sarah A. Blomquist; Laurel M. Johnstone; Chandra Tontsch; Qibin Qi; Ingo Ruczinski; Stephen S. Rich; Rasika A. Mathias; Floyd H. Chilton; Ani Manichaikul

doi:10.1038/s42003-021-02431-4

Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

Chaojie Yang, Brian Hallmark, Jin Choul Chai, Timothy D. O’Connor, Lindsay M. Reynolds, Alexis C. Wood, Michael Seeds, Yii Der Ida Chen, Lyn M. Steffen, Michael Y. Tsai, Robert C. Kaplan, Martha L. Daviglus, Lawrence J. Mandarino, Amanda M. Fretts, Rozenn N. Lemaitre, Dawn K. Coletta, Sarah A. Blomquist, Laurel M. Johnstone, Chandra Tontsch, Qibin QiIngo Ruczinski, Stephen S. Rich, Rasika A. Mathias, Floyd H. Chilton, Ani Manichaikul

Research output: Contribution to journal › Article › peer-review

Abstract

Long chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this study, we examined relationships between genetic ancestry and FADS variation in 1102 Hispanic American participants from the Multi-Ethnic Study of Atherosclerosis. We demonstrate strong negative associations between Amerind genetic ancestry and LC-PUFA levels. The FADS rs174537 single nucleotide polymorphism (SNP) accounted for much of the AI ancestry effect on LC-PUFAs, especially for low levels of n-3 LC-PUFAs. Rs174537 was also strongly associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides (TGs) and E-selectin in MESA Hispanics. Our study demonstrates that Amerind ancestry provides a useful and readily available tool to identify individuals most likely to have FADS-related n-3 LC-PUFA deficiencies and associated cardiovascular risk.

Original language	English (US)
Article number	918
Journal	Communications biology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1038/s42003-021-02431-4
State	Published - Dec 2021

ASJC Scopus subject areas

Medicine (miscellaneous)
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1038/s42003-021-02431-4

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Yang, C., Hallmark, B., Chai, J. C., O’Connor, T. D., Reynolds, L. M., Wood, A. C., Seeds, M., Chen, Y. D. I., Steffen, L. M., Tsai, M. Y., Kaplan, R. C., Daviglus, M. L., Mandarino, L. J., Fretts, A. M., Lemaitre, R. N., Coletta, D. K., Blomquist, S. A., Johnstone, L. M., Tontsch, C., ... Manichaikul, A. (2021). Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations. Communications biology, 4(1), Article 918. https://doi.org/10.1038/s42003-021-02431-4

Yang, C, Hallmark, B, Chai, JC, O’Connor, TD, Reynolds, LM, Wood, AC, Seeds, M, Chen, YDI, Steffen, LM, Tsai, MY, Kaplan, RC, Daviglus, ML, Mandarino, LJ, Fretts, AM, Lemaitre, RN, Coletta, DK, Blomquist, SA, Johnstone, LM, Tontsch, C, Qi, Q, Ruczinski, I, Rich, SS, Mathias, RA, Chilton, FH & Manichaikul, A 2021, 'Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations', Communications biology, vol. 4, no. 1, 918. https://doi.org/10.1038/s42003-021-02431-4

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title = "Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations",

abstract = "Long chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this study, we examined relationships between genetic ancestry and FADS variation in 1102 Hispanic American participants from the Multi-Ethnic Study of Atherosclerosis. We demonstrate strong negative associations between Amerind genetic ancestry and LC-PUFA levels. The FADS rs174537 single nucleotide polymorphism (SNP) accounted for much of the AI ancestry effect on LC-PUFAs, especially for low levels of n-3 LC-PUFAs. Rs174537 was also strongly associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides (TGs) and E-selectin in MESA Hispanics. Our study demonstrates that Amerind ancestry provides a useful and readily available tool to identify individuals most likely to have FADS-related n-3 LC-PUFA deficiencies and associated cardiovascular risk.",

author = "Chaojie Yang and Brian Hallmark and Chai, {Jin Choul} and O{\textquoteright}Connor, {Timothy D.} and Reynolds, {Lindsay M.} and Wood, {Alexis C.} and Michael Seeds and Chen, {Yii Der Ida} and Steffen, {Lyn M.} and Tsai, {Michael Y.} and Kaplan, {Robert C.} and Daviglus, {Martha L.} and Mandarino, {Lawrence J.} and Fretts, {Amanda M.} and Lemaitre, {Rozenn N.} and Coletta, {Dawn K.} and Blomquist, {Sarah A.} and Johnstone, {Laurel M.} and Chandra Tontsch and Qibin Qi and Ingo Ruczinski and Rich, {Stephen S.} and Mathias, {Rasika A.} and Chilton, {Floyd H.} and Ani Manichaikul",

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year = "2021",

month = dec,

doi = "10.1038/s42003-021-02431-4",

language = "English (US)",

volume = "4",

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T1 - Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

AU - Yang, Chaojie

AU - Hallmark, Brian

AU - Chai, Jin Choul

AU - O’Connor, Timothy D.

AU - Reynolds, Lindsay M.

AU - Wood, Alexis C.

AU - Seeds, Michael

AU - Chen, Yii Der Ida

AU - Steffen, Lyn M.

AU - Tsai, Michael Y.

AU - Kaplan, Robert C.

AU - Daviglus, Martha L.

AU - Mandarino, Lawrence J.

AU - Fretts, Amanda M.

AU - Lemaitre, Rozenn N.

AU - Coletta, Dawn K.

AU - Blomquist, Sarah A.

AU - Johnstone, Laurel M.

AU - Tontsch, Chandra

AU - Qi, Qibin

AU - Ruczinski, Ingo

AU - Rich, Stephen S.

AU - Mathias, Rasika A.

AU - Chilton, Floyd H.

AU - Manichaikul, Ani

PY - 2021/12

Y1 - 2021/12

N2 - Long chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this study, we examined relationships between genetic ancestry and FADS variation in 1102 Hispanic American participants from the Multi-Ethnic Study of Atherosclerosis. We demonstrate strong negative associations between Amerind genetic ancestry and LC-PUFA levels. The FADS rs174537 single nucleotide polymorphism (SNP) accounted for much of the AI ancestry effect on LC-PUFAs, especially for low levels of n-3 LC-PUFAs. Rs174537 was also strongly associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides (TGs) and E-selectin in MESA Hispanics. Our study demonstrates that Amerind ancestry provides a useful and readily available tool to identify individuals most likely to have FADS-related n-3 LC-PUFA deficiencies and associated cardiovascular risk.

AB - Long chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this study, we examined relationships between genetic ancestry and FADS variation in 1102 Hispanic American participants from the Multi-Ethnic Study of Atherosclerosis. We demonstrate strong negative associations between Amerind genetic ancestry and LC-PUFA levels. The FADS rs174537 single nucleotide polymorphism (SNP) accounted for much of the AI ancestry effect on LC-PUFAs, especially for low levels of n-3 LC-PUFAs. Rs174537 was also strongly associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides (TGs) and E-selectin in MESA Hispanics. Our study demonstrates that Amerind ancestry provides a useful and readily available tool to identify individuals most likely to have FADS-related n-3 LC-PUFA deficiencies and associated cardiovascular risk.

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JF - Communications biology

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ER -

Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

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