Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly

Ira Driscoll, Susan M. Resnick, Juan C Troncoso, Yang An, Richard O'Brien, Alan B. Zonderman

Research output: Contribution to journalArticle

Abstract

Objective: Some individuals who are asymptomatic for dementia while alive have substantial Alzheimer's disease (AD) neuropathology at autopsy. We investigated whether cognitive trajectories differ between clinically normal elderly individuals with and without AD neuropathology and how they compare with trajectories of clinically impaired individuals before dementia diagnosis. Methods: Eighty-one elderly participants in the Baltimore Longitudinal Study of Aging (BLSA) were followed prospectively with neurological and neuropsychological assessments before autopsy evaluation at death. Trajectories of cognitive change were estimated for a number of domains using cognitive data before a clinical diagnosis of dementia. Results: Clinically normal elderly individuals with and without AD-type neuropathology have similar cognitive trajectories across different cognitive domains. In contrast, individuals with mild cognitive impairment/AD show steeper rates of longitudinal decline in several aspects of cognition compared with clinically normal elderly individuals regardless of whether the latter have AD neuropathology. Moreover, the cognitive differences between impaired and unimpaired groups can be detected years before a diagnosis of dementia. Interpretation: Clinically normal individuals with and without AD neuropathology do not differ in rates of cognitive decline across a number of cognitive domains. Understanding the factors that protect some individuals with AD pathology from cognitive impairment may contribute to the maintenance of cognitive health in the elderly.

Original languageEnglish (US)
Pages (from-to)688-695
Number of pages8
JournalAnnals of Neurology
Volume60
Issue number6
DOIs
StatePublished - Dec 2006

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Alzheimer Disease
Pathology
Dementia
Autopsy
Baltimore
Cognition
Longitudinal Studies
Neuropathology
Health
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly. / Driscoll, Ira; Resnick, Susan M.; Troncoso, Juan C; An, Yang; O'Brien, Richard; Zonderman, Alan B.

In: Annals of Neurology, Vol. 60, No. 6, 12.2006, p. 688-695.

Research output: Contribution to journalArticle

Driscoll, I, Resnick, SM, Troncoso, JC, An, Y, O'Brien, R & Zonderman, AB 2006, 'Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly', Annals of Neurology, vol. 60, no. 6, pp. 688-695. https://doi.org/10.1002/ana.21031
Driscoll, Ira ; Resnick, Susan M. ; Troncoso, Juan C ; An, Yang ; O'Brien, Richard ; Zonderman, Alan B. / Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly. In: Annals of Neurology. 2006 ; Vol. 60, No. 6. pp. 688-695.
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