Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients

Patricia García de Olalla, Hernando Knobel, Alexia Carmona, Ana Guelar, José L. Lôpez-Colomés, Joan A. Caylà

Research output: Contribution to journalArticle

Abstract

Objectives: To assess the effect of antiretroviral therapy (ART) adherence on survival in HIV-infected patients. Design: Cohort study at a single hospital in Barcelona, Spain. Methods: Data on HIV-infected patients older than 18 years of age who began ART during the period 1990 to 1999 were analyzed. Patients were considered nonadherent if the total dose of antiretroviral drug was less than 90% of that prescribed. Adherence was assessed through self-report and hospital pharmacy appointments. Cox regression with time-dependent variables was used. Results: A total of 1219 patients were included. The first ART was with monotherapy in 23.7% of cases, with two drugs in 30.5%, and with triple therapy in 45.8%. In multivariate analysis, the variables that presented significant differences with respect to mortality were clinical stage at the beginning of treatment (AIDS: relative hazard (RH) = 2.97; 95% confidence interval [CI]: 2.14-4.13), CD4 cell count (

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume30
Issue number1
DOIs
StatePublished - May 1 2002
Externally publishedYes

Fingerprint

Highly Active Antiretroviral Therapy
HIV
Survival
Therapeutics
CD4 Lymphocyte Count
Pharmaceutical Preparations
Spain
Self Report
Appointments and Schedules
Acquired Immunodeficiency Syndrome
Cohort Studies
Multivariate Analysis
Confidence Intervals
Mortality

Keywords

  • Adherence
  • HAART
  • HIV infection
  • Survival

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

García de Olalla, P., Knobel, H., Carmona, A., Guelar, A., Lôpez-Colomés, J. L., & Caylà, J. A. (2002). Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients. Journal of Acquired Immune Deficiency Syndromes, 30(1), 105-110. https://doi.org/10.1097/00126334-200205010-00014

Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients. / García de Olalla, Patricia; Knobel, Hernando; Carmona, Alexia; Guelar, Ana; Lôpez-Colomés, José L.; Caylà, Joan A.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 30, No. 1, 01.05.2002, p. 105-110.

Research output: Contribution to journalArticle

García de Olalla, P, Knobel, H, Carmona, A, Guelar, A, Lôpez-Colomés, JL & Caylà, JA 2002, 'Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients', Journal of Acquired Immune Deficiency Syndromes, vol. 30, no. 1, pp. 105-110. https://doi.org/10.1097/00126334-200205010-00014
García de Olalla, Patricia ; Knobel, Hernando ; Carmona, Alexia ; Guelar, Ana ; Lôpez-Colomés, José L. ; Caylà, Joan A. / Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients. In: Journal of Acquired Immune Deficiency Syndromes. 2002 ; Vol. 30, No. 1. pp. 105-110.
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