Impact of acute kidney injury on distant organ function: Recent findings and potential therapeutic targets

Kent Doi, Hamid Rabb

Research output: Contribution to journalReview article

Abstract

Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in preclinical models, no specific agent has been shown to benefit AKI in humans. Moreover, despite remarkable advances in dialysis techniques that enable management of AKI in hemodynamically unstable patients with shock, dialysis-requiring severe AKI is still associated with an unacceptably high mortality rate. Thus, focusing only on kidney damage and loss of renal function has not been sufficient to improve outcomes of patients with AKI. Recent data from basic and clinical research have begun to elucidate complex organ interactions in AKI between kidney and distant organs, including heart, lung, spleen, brain, liver, and gut. This review serves to update the topic of organ cross talk in AKI and focuses on potential therapeutic targets to improve patient outcomes during AKI-associated multiple organ failure.

Original languageEnglish (US)
Pages (from-to)555-564
Number of pages10
JournalKidney international
Volume89
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • acute kidney injury
  • inflammation
  • ischemia reperfusion
  • sepsis

ASJC Scopus subject areas

  • Nephrology

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