Impact of ABO compatibility on outcomes after heart transplantation in a national cohort during the past decade

Oliver K. Jawitz, Nicole G. Jawitz, David D. Yuh, Pramod Bonde

Research output: Contribution to journalArticle

Abstract

Background Immunologic incompatibility has implications for primary graft failure, rejection, and survival in heart transplantation. To our knowledge, this is the first large cohort study investigating the impact of ABO-compatible versus identical blood type matching on post heart transplantation survival. Methods We used a nationwide sample (2000-2010) within the United Network for Organ Sharing database. Stratification was between ABO-identical and ABO-compatible heart transplantations for univariate and multivariate analyses. The primary end point was graft failure from all causes. Posttransplant survival was compared between groups using Cox proportional hazard and logistic regression models. Results A total of 17,951 patients met inclusion criteria, and 2684 (approximately 15%) underwent ABO-compatible heart transplantation. ABO-compatible recipients were generally sicker than ABO-identical recipients before transplant because more were status 1A, in the intensive care unit, and receiving mechanical ventilatory support (P

Original languageEnglish (US)
Pages (from-to)1239-1246
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume146
Issue number5
DOIs
StatePublished - Nov 2013
Externally publishedYes

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Heart Transplantation
Logistic Models
Survival
Graft Rejection
Graft Survival
Intensive Care Units
Cohort Studies
Multivariate Analysis
Databases
Transplants

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Impact of ABO compatibility on outcomes after heart transplantation in a national cohort during the past decade. / Jawitz, Oliver K.; G. Jawitz, Nicole; Yuh, David D.; Bonde, Pramod.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 146, No. 5, 11.2013, p. 1239-1246.

Research output: Contribution to journalArticle

Jawitz, Oliver K. ; G. Jawitz, Nicole ; Yuh, David D. ; Bonde, Pramod. / Impact of ABO compatibility on outcomes after heart transplantation in a national cohort during the past decade. In: Journal of Thoracic and Cardiovascular Surgery. 2013 ; Vol. 146, No. 5. pp. 1239-1246.
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