Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma

Franz O. Smith, Jacob A. Klapper, John R. Wunderlich, Steven A. Rosenberg, Mark E. Dudley

Research output: Contribution to journalArticle

Abstract

A patient with metastatic melanoma who had progressive disease after prior surgical resections, high dose interleukin-2, and anti-cytotoxic T lymphocyte antigen-4 antibody received sequential treatments with autologous tumor infiltrating lymphocytes that recognized the gp100 melanocyte differentiation antigen. Although no clinical response was seen when cells were administered alone, an objective clinical response to therapy was seen with tumor infiltrating lymphocytes administered together with a highly immunogenic fowlpox vaccine expressing a gp100: 209-217 (210M) epitope. Persistence of the transferred antigen-specific lymphocytes in the peripheral blood was observed only after adoptive cell therapy plus administration of vaccine. Cell proliferation in vitro was further stimulated by additional vaccine and interleukin-2. The patient has an ongoing partial response at 10 months after the last treatment.

Original languageEnglish (US)
Pages (from-to)870-874
Number of pages5
JournalJournal of Immunotherapy
Volume32
Issue number8
DOIs
StatePublished - Oct 2009
Externally publishedYes

Fingerprint

Fowlpox
Tumor-Infiltrating Lymphocytes
Synthetic Vaccines
Cell- and Tissue-Based Therapy
Melanoma
Vaccines
Interleukin-2
gp100 Melanoma Antigen
CTLA-4 Antigen
Epitopes
Therapeutics
Cell Proliferation
Lymphocytes
Antigens
Antibodies

Keywords

  • Adoptive cell therapy
  • Gp100: 209-217 (210M)
  • Metastatic melanoma
  • Recombinant fowlpox vaccine
  • Tumor infiltrating lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Cancer Research
  • Pharmacology

Cite this

Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma. / Smith, Franz O.; Klapper, Jacob A.; Wunderlich, John R.; Rosenberg, Steven A.; Dudley, Mark E.

In: Journal of Immunotherapy, Vol. 32, No. 8, 10.2009, p. 870-874.

Research output: Contribution to journalArticle

Smith, Franz O. ; Klapper, Jacob A. ; Wunderlich, John R. ; Rosenberg, Steven A. ; Dudley, Mark E. / Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma. In: Journal of Immunotherapy. 2009 ; Vol. 32, No. 8. pp. 870-874.
@article{074cfa33a1ad499797b7e65a728c3c3a,
title = "Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma",
abstract = "A patient with metastatic melanoma who had progressive disease after prior surgical resections, high dose interleukin-2, and anti-cytotoxic T lymphocyte antigen-4 antibody received sequential treatments with autologous tumor infiltrating lymphocytes that recognized the gp100 melanocyte differentiation antigen. Although no clinical response was seen when cells were administered alone, an objective clinical response to therapy was seen with tumor infiltrating lymphocytes administered together with a highly immunogenic fowlpox vaccine expressing a gp100: 209-217 (210M) epitope. Persistence of the transferred antigen-specific lymphocytes in the peripheral blood was observed only after adoptive cell therapy plus administration of vaccine. Cell proliferation in vitro was further stimulated by additional vaccine and interleukin-2. The patient has an ongoing partial response at 10 months after the last treatment.",
keywords = "Adoptive cell therapy, Gp100: 209-217 (210M), Metastatic melanoma, Recombinant fowlpox vaccine, Tumor infiltrating lymphocytes",
author = "Smith, {Franz O.} and Klapper, {Jacob A.} and Wunderlich, {John R.} and Rosenberg, {Steven A.} and Dudley, {Mark E.}",
year = "2009",
month = "10",
doi = "10.1097/CJI.0b013e3181b36b69",
language = "English (US)",
volume = "32",
pages = "870--874",
journal = "Journal of Immunotherapy",
issn = "1524-9557",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma

AU - Smith, Franz O.

AU - Klapper, Jacob A.

AU - Wunderlich, John R.

AU - Rosenberg, Steven A.

AU - Dudley, Mark E.

PY - 2009/10

Y1 - 2009/10

N2 - A patient with metastatic melanoma who had progressive disease after prior surgical resections, high dose interleukin-2, and anti-cytotoxic T lymphocyte antigen-4 antibody received sequential treatments with autologous tumor infiltrating lymphocytes that recognized the gp100 melanocyte differentiation antigen. Although no clinical response was seen when cells were administered alone, an objective clinical response to therapy was seen with tumor infiltrating lymphocytes administered together with a highly immunogenic fowlpox vaccine expressing a gp100: 209-217 (210M) epitope. Persistence of the transferred antigen-specific lymphocytes in the peripheral blood was observed only after adoptive cell therapy plus administration of vaccine. Cell proliferation in vitro was further stimulated by additional vaccine and interleukin-2. The patient has an ongoing partial response at 10 months after the last treatment.

AB - A patient with metastatic melanoma who had progressive disease after prior surgical resections, high dose interleukin-2, and anti-cytotoxic T lymphocyte antigen-4 antibody received sequential treatments with autologous tumor infiltrating lymphocytes that recognized the gp100 melanocyte differentiation antigen. Although no clinical response was seen when cells were administered alone, an objective clinical response to therapy was seen with tumor infiltrating lymphocytes administered together with a highly immunogenic fowlpox vaccine expressing a gp100: 209-217 (210M) epitope. Persistence of the transferred antigen-specific lymphocytes in the peripheral blood was observed only after adoptive cell therapy plus administration of vaccine. Cell proliferation in vitro was further stimulated by additional vaccine and interleukin-2. The patient has an ongoing partial response at 10 months after the last treatment.

KW - Adoptive cell therapy

KW - Gp100: 209-217 (210M)

KW - Metastatic melanoma

KW - Recombinant fowlpox vaccine

KW - Tumor infiltrating lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=70349656913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349656913&partnerID=8YFLogxK

U2 - 10.1097/CJI.0b013e3181b36b69

DO - 10.1097/CJI.0b013e3181b36b69

M3 - Article

C2 - 19752747

AN - SCOPUS:70349656913

VL - 32

SP - 870

EP - 874

JO - Journal of Immunotherapy

JF - Journal of Immunotherapy

SN - 1524-9557

IS - 8

ER -