Impact of a new vaccine clinic on hepatitis B vaccine completion and immunological response rates in an HIV-positive cohort

Clare Rock, Eoghan de Barra, Corinna Sadlier, Sinead Kelly, Catherine Dowling, Cora McNally, Colm Bergin

Research output: Contribution to journalArticle

Abstract

Introduction: Hepatitis B virus vaccination (HBVV) in the HIV-infected population has poor reported completion rates and immunological response rates. At our HIV clinic, we established a vaccine clinic to improve HBVV outcomes using interventions such as SMS text reminders and double-dose (DD) HBVV for standard-dose non-responders (SD NRs). Methods: A five-year (2003-2008) retrospective review of the completion rates and immunological response rates for HBVV after the establishment of the dedicated vaccine clinic was conducted. Statistical significance was assumed at p<. 0.05, and the analysis was performed using SPSS (v16). Results: A total of 354 HIV-infected patients were included. Seventy-five percent (268/354) of patients completed the SD HBVV, an 84% (226/268) returned for the hepatitis B surface antibody evaluation. Only 47.3% (107/226) responded to standard-dose hepatitis B vaccination. Responders had higher absolute numbers (. p=. 0.017) and percentages of CD4 cells (. p<. 0.001) and were more likely to be receiving HAART (. p=. 0.001). There was a 70% (48/69) response rate to DD HBVV among SD NRs. On-treatment analysis showed an 88% (155/176) overall immunological response to SD HBVV and DD HBVV, if required. Conclusion: High HBVV completion and response rates in this HIV cohort were enabled through the use of multiple interventions, including the use of SMS text message reminders and routine referral for DD vaccination.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalJournal of Infection and Public Health
Volume6
Issue number3
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

Keywords

  • HIV
  • Hepatitis B
  • Hepatitis B vaccination
  • Hepatitis B vaccination outcomes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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