Impact of a multiplex PCR point-of-care test for influenza A/B and respiratory syncytial virus on an acute pediatric hospital ward

Andres I. Vecino-Ortiz, Simon D. Goldenberg, Sam T. Douthwaite, Chih Yuan Cheng, Rebecca E. Glover, Catherine Mak, Elisabeth J. Adams

Research output: Contribution to journalArticle

Abstract

Patients with respiratory infections are often managed presumptively until confirmation of infection status. We assessed the impact of introducing the Enigma® MiniLab™ FluAB-RSV point-of-care test (POCT) on patients admitted with a suspected respiratory virus driven illness in an acute pediatric ward. This utilized a before and after design (respiratory viral seasons 2013/14 versus 2014/15). Following POCT implementation, oseltamivir prescribing increased in patients with influenza (OR = 12.7, P = 0.05, 95% CI [1.0, 153.8]). A reduction in the average reimbursement charges without a change in the length of stay was observed. Modeling suggested that laboratory test cost savings could be achieved if the POCT cost £30 and was used for screening, followed by the respiratory viral panel for RSV and influenza negative patients. A rapid POCT for influenza A/B and RSV infections in pediatric inpatients may improve oseltamivir prescribing, strengthen antimicrobial stewardship, reduce reimbursement charges and decrease laboratory costs.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume91
Issue number4
DOIs
StatePublished - Aug 1 2018

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Point-of-Care Systems
Pediatric Hospitals
Respiratory Syncytial Viruses
Multiplex Polymerase Chain Reaction
Human Influenza
Oseltamivir
Pediatrics
Costs and Cost Analysis
Cost Savings
Infection
Respiratory Tract Infections
Inpatients
Length of Stay
Viruses

Keywords

  • Influenza virus A
  • Influenza virus B
  • Point-of-care technology
  • Rapid diagnostic tests
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Impact of a multiplex PCR point-of-care test for influenza A/B and respiratory syncytial virus on an acute pediatric hospital ward. / Vecino-Ortiz, Andres I.; Goldenberg, Simon D.; Douthwaite, Sam T.; Cheng, Chih Yuan; Glover, Rebecca E.; Mak, Catherine; Adams, Elisabeth J.

In: Diagnostic Microbiology and Infectious Disease, Vol. 91, No. 4, 01.08.2018, p. 331-335.

Research output: Contribution to journalArticle

Vecino-Ortiz, Andres I. ; Goldenberg, Simon D. ; Douthwaite, Sam T. ; Cheng, Chih Yuan ; Glover, Rebecca E. ; Mak, Catherine ; Adams, Elisabeth J. / Impact of a multiplex PCR point-of-care test for influenza A/B and respiratory syncytial virus on an acute pediatric hospital ward. In: Diagnostic Microbiology and Infectious Disease. 2018 ; Vol. 91, No. 4. pp. 331-335.
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