Impact of a multiplex PCR point-of-care test for influenza A/B and respiratory syncytial virus on an acute pediatric hospital ward

Andres I. Vecino-Ortiz, Simon D. Goldenberg, Sam T. Douthwaite, Chih Yuan Cheng, Rebecca E. Glover, Catherine Mak, Elisabeth J. Adams

Research output: Contribution to journalArticle

Abstract

Patients with respiratory infections are often managed presumptively until confirmation of infection status. We assessed the impact of introducing the Enigma® MiniLab™ FluAB-RSV point-of-care test (POCT) on patients admitted with a suspected respiratory virus driven illness in an acute pediatric ward. This utilized a before and after design (respiratory viral seasons 2013/14 versus 2014/15). Following POCT implementation, oseltamivir prescribing increased in patients with influenza (OR = 12.7, P = 0.05, 95% CI [1.0, 153.8]). A reduction in the average reimbursement charges without a change in the length of stay was observed. Modeling suggested that laboratory test cost savings could be achieved if the POCT cost £30 and was used for screening, followed by the respiratory viral panel for RSV and influenza negative patients. A rapid POCT for influenza A/B and RSV infections in pediatric inpatients may improve oseltamivir prescribing, strengthen antimicrobial stewardship, reduce reimbursement charges and decrease laboratory costs.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume91
Issue number4
DOIs
StatePublished - Aug 2018

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Keywords

  • Influenza virus A
  • Influenza virus B
  • Point-of-care technology
  • Rapid diagnostic tests
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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