Impact of a combined intravenous/intra-arterial approach in octogenarians

Mikael Mazighi, Julien Labreuche, Elena Meseguer, Jean Michel Serfaty, Jean Pierre Laissy, Philippa C. Lavallée, Lucie Cabrejo, Céline Guidoux, Bertrand Lapergue, Isabelle F. Klein, Jean Marc Olivot, Halim Abboud, Olivier Simon, Elisabeth Schouman-Claeys, Pierre Amarenco

Research output: Contribution to journalArticle

Abstract

Background: Intravenous (IV) alteplase is not currently recommended in octogenarian patients, and the benefit/risk ratio of endovascular (intra-arterial, IA) therapy remains to be determined. The aim of this study was to determine the impact of a combined IV-IA approach in octogenarians. Methods: From a single-centre interventional study, we report age-specific outcomes of patients treated by a combined IV-IA thrombolytic approach. Patients ≥80 years with documented arterial occlusion treated by conventional IV thrombolysis constituted the control group. Results: Among 84 patients treated by the IV-IA approach, those ≥80 years (n = 25) had a similar rate of early neurological improvement to that of patients

Original languageEnglish (US)
Pages (from-to)559-565
Number of pages7
JournalCerebrovascular Diseases
Volume31
Issue number6
DOIs
StatePublished - May 2011
Externally publishedYes

Keywords

  • Alteplase
  • Combined intravenous/intra-arterial approach
  • Octogenarians
  • Recombinant tissue plasminogen activator

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Mazighi, M., Labreuche, J., Meseguer, E., Serfaty, J. M., Laissy, J. P., Lavallée, P. C., Cabrejo, L., Guidoux, C., Lapergue, B., Klein, I. F., Olivot, J. M., Abboud, H., Simon, O., Schouman-Claeys, E., & Amarenco, P. (2011). Impact of a combined intravenous/intra-arterial approach in octogenarians. Cerebrovascular Diseases, 31(6), 559-565. https://doi.org/10.1159/000324626