Impact and Effectiveness of State-Level Tuberculosis Interventions in California, Florida, New York, and Texas

A Model-Based Analysis

Sourya Shrestha, Sarah Cherng, Andrew N. Hill, Sue Reynolds, Jennifer Flood, Pennan M. Barry, Adam Readhead, Margaret Oxtoby, Michael Lauzardo, Tom Privett, Suzanne M. Marks, David Wesley Dowdy

Research output: Contribution to journalArticle

Abstract

The incidence of tuberculosis (TB) in the United States has stabilized, and additional interventions are needed to make progress toward TB elimination. However, the impact of such interventions depends on local demography and the heterogeneity of populations at risk. Using state-level individual-based TB transmission models calibrated to California, Florida, New York, and Texas, we modeled 2 TB interventions: 1) increased targeted testing and treatment (TTT) of high-risk populations, including people who are non-US-born, diabetic, human immunodeficiency virus (HIV)-positive, homeless, or incarcerated; and 2) enhanced contact investigation (ECI) for contacts of TB patients, including higher completion of preventive therapy. For each intervention, we projected reductions in active TB incidence over 10 years (2016-2026) and numbers needed to screen and treat in order to avert 1 case. We estimated that TTT delivered to half of the non-US-born adult population could lower TB incidence by 19.8%-26.7% over a 10-year period. TTT delivered to smaller populations with higher TB risk (e.g., HIV-positive persons, homeless persons) and ECI were generally more efficient but had less overall impact on incidence. TTT targeted to smaller, highest-risk populations and ECI can be highly efficient; however, major reductions in incidence will only be achieved by also targeting larger, moderate-risk populations. Ultimately, to eliminate TB in the United States, a combination of these approaches will be necessary.

Original languageEnglish (US)
Pages (from-to)1733-1741
Number of pages9
JournalAmerican journal of epidemiology
Volume188
Issue number9
DOIs
StatePublished - Sep 1 2019

Fingerprint

Tuberculosis
Incidence
Population
HIV
Therapeutics
Homeless Persons
Numbers Needed To Treat
Demography

Keywords

  • mathematical modeling
  • preventative therapy
  • tuberculosis
  • tuberculosis prevention

ASJC Scopus subject areas

  • Epidemiology

Cite this

Impact and Effectiveness of State-Level Tuberculosis Interventions in California, Florida, New York, and Texas : A Model-Based Analysis. / Shrestha, Sourya; Cherng, Sarah; Hill, Andrew N.; Reynolds, Sue; Flood, Jennifer; Barry, Pennan M.; Readhead, Adam; Oxtoby, Margaret; Lauzardo, Michael; Privett, Tom; Marks, Suzanne M.; Dowdy, David Wesley.

In: American journal of epidemiology, Vol. 188, No. 9, 01.09.2019, p. 1733-1741.

Research output: Contribution to journalArticle

Shrestha, S, Cherng, S, Hill, AN, Reynolds, S, Flood, J, Barry, PM, Readhead, A, Oxtoby, M, Lauzardo, M, Privett, T, Marks, SM & Dowdy, DW 2019, 'Impact and Effectiveness of State-Level Tuberculosis Interventions in California, Florida, New York, and Texas: A Model-Based Analysis', American journal of epidemiology, vol. 188, no. 9, pp. 1733-1741. https://doi.org/10.1093/aje/kwz147
Shrestha, Sourya ; Cherng, Sarah ; Hill, Andrew N. ; Reynolds, Sue ; Flood, Jennifer ; Barry, Pennan M. ; Readhead, Adam ; Oxtoby, Margaret ; Lauzardo, Michael ; Privett, Tom ; Marks, Suzanne M. ; Dowdy, David Wesley. / Impact and Effectiveness of State-Level Tuberculosis Interventions in California, Florida, New York, and Texas : A Model-Based Analysis. In: American journal of epidemiology. 2019 ; Vol. 188, No. 9. pp. 1733-1741.
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