Impact and costs of targeted recruitment of minorities to the National Lung Screening Trial

Catherine Duda, Irene Mahon, Mei Hsiu Chen, Bradley Snyder, Richard Barrd, Caroline Chiles, Robert Falk, Elliot K Fishman, David Gemmel, Jonathan G. Goldin, Kathleen Brown, Reginald F. Munden, Kay Vydareny, Denise R. Aberle

Research output: Contribution to journalArticle


Background: To promote results in the National Lung Screening Trial (NLST) that are generalizable across the entire US population, a subset of NLST sites developed dedicated strategies for minority recruitment. Purpose: To report the effects of targeted strategies on the accrual of underrepresented groups, to describe participant characteristics, and to estimate the costs of targeted enrollment. Methods: The 2002-2004 Tobacco Use Supplement was used to estimate eligible proportions of racial and ethnic categories. Strategic planning included meetings/conferences with key stakeholders and minority organizations. Potential institutions were selected based upon regional racial/ethnic diversity and proven success in recruitment of underrepresented groups. Seven institutions submitted targeted recruitment strategies with budgets. Accrual by racial/ethnic category was tracked for each institution. Cost estimates were based on itemized receipts for minority strategies relative to minority accrual. Results: Of 18,842 participants enrolled, 1576 (8.4%) were minority participants. The seven institutions with targeted recruitment strategies accounted for 1223 (77.6%) of all minority participants enrolled. While there was a significant increase in the rate of minority accrual pre-implementation to post-implementation for the institutions with targeted recruitment (9.3% vs. 15.2%, p

Original languageEnglish (US)
Pages (from-to)214-223
Number of pages10
JournalClinical Trials
Issue number2
Publication statusPublished - Apr 2011


ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology

Cite this

Duda, C., Mahon, I., Chen, M. H., Snyder, B., Barrd, R., Chiles, C., ... Aberle, D. R. (2011). Impact and costs of targeted recruitment of minorities to the National Lung Screening Trial. Clinical Trials, 8(2), 214-223.