Immunotoxicity of medical devices

Kathleen Rodgers, Paal Klykken, Joshua Jacobs, Carmelita Frondoza, Vesna Tomazic, Judith Zelikoff

Research output: Contribution to journalArticle

Abstract

Determination of the ability of a medical device to interact with the immune system currently involves assessment of the immunogenic potential and biocompatibility of the device or an extract of the device. However, implants are often in the body for extended periods of time and/or are placed by a surgical procedure that in and of itself will generate an acute inflammatory response. This symposium discussed studies that have been performed to evaluate the immunogenicity of various devices consisting of several different compositions (i.e., silicone, metals, and latex) in contact with different anatomical sites, the ability of a device to modulate an inflammatory response generated by a surgical procedure or trauma, and the response of the body to a material left in place for extended periods of time. This symposium brought together scientists from many different disciplines to begin to identify and fill in the gaps in this area.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalFundamental and Applied Toxicology
Volume36
Issue number1
DOIs
StatePublished - Mar 1997

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ASJC Scopus subject areas

  • Toxicology

Cite this

Rodgers, K., Klykken, P., Jacobs, J., Frondoza, C., Tomazic, V., & Zelikoff, J. (1997). Immunotoxicity of medical devices. Fundamental and Applied Toxicology, 36(1), 1-14. https://doi.org/10.1006/faat.1996.2279