Immunotherapy of murine leukemia. V. Protection against friend leukemia virus-induced immune complex glomerulonephritis by passive serum therapy

F. Sanfilippo, E. V. Genovesi, J. J. Collins

Research output: Contribution to journalArticle

Abstract

The development of immune complex glomerulonephritis in DBA/2 mice infected with Friend murine leukemia virus (F-MuLV) was compared with that in mice protected against virus-induced disease by administration of chimpanzee anti-F-MuLV antiserum (CaF-MuLV). Morphologic analysis of glomeruli from viremic (infected) normal chimpanzee serum-treated animals revealed significant renal disease within 2 weeks following virus inoculation, with glomerular immune complex deposits and C-type viral particles seen by electron microscopy. Localization of F-MuLV envelope and core antigens (gp71 and p30, respectively) was also detected by immunofluorescence, as was murine IG and C3. However, age-matched DBA/2 mice treated with CaF-MuLV antiserum alone or following F-MuLV inoculation showed no evidence of systemic disease and neither localization of F-MuLV antigens nor detectable virus particles. These data indicate that in addition to erythroleukemia, F-MuLV infection results in severe immune complex glomerulonephritis and that passive immunotherapy can protect susceptible mice from both aspects of viral pathogenesis.

Original languageEnglish (US)
Pages (from-to)703-717
Number of pages15
JournalJournal of the National Cancer Institute
Volume67
Issue number3
StatePublished - 1981
Externally publishedYes

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Friend murine leukemia virus
Glomerulonephritis
Antigen-Antibody Complex
Immunotherapy
Leukemia
Pan troglodytes
Serum
Immune Sera
Inbred DBA Mouse
Virus Diseases
Virion
Therapeutics
Antigens
Leukemia, Erythroblastic, Acute
Passive Immunization
Fluorescent Antibody Technique
Electron Microscopy
Viruses
Kidney

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Immunotherapy of murine leukemia. V. Protection against friend leukemia virus-induced immune complex glomerulonephritis by passive serum therapy. / Sanfilippo, F.; Genovesi, E. V.; Collins, J. J.

In: Journal of the National Cancer Institute, Vol. 67, No. 3, 1981, p. 703-717.

Research output: Contribution to journalArticle

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AB - The development of immune complex glomerulonephritis in DBA/2 mice infected with Friend murine leukemia virus (F-MuLV) was compared with that in mice protected against virus-induced disease by administration of chimpanzee anti-F-MuLV antiserum (CaF-MuLV). Morphologic analysis of glomeruli from viremic (infected) normal chimpanzee serum-treated animals revealed significant renal disease within 2 weeks following virus inoculation, with glomerular immune complex deposits and C-type viral particles seen by electron microscopy. Localization of F-MuLV envelope and core antigens (gp71 and p30, respectively) was also detected by immunofluorescence, as was murine IG and C3. However, age-matched DBA/2 mice treated with CaF-MuLV antiserum alone or following F-MuLV inoculation showed no evidence of systemic disease and neither localization of F-MuLV antigens nor detectable virus particles. These data indicate that in addition to erythroleukemia, F-MuLV infection results in severe immune complex glomerulonephritis and that passive immunotherapy can protect susceptible mice from both aspects of viral pathogenesis.

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