Immunotherapy of murine leukemia. V. Protection against friend leukemia virus-induced immune complex glomerulonephritis by passive serum therapy

F. Sanfilippo, E. V. Genovesi, J. J. Collins

Research output: Contribution to journalArticle

Abstract

The development of immune complex glomerulonephritis in DBA/2 mice infected with Friend murine leukemia virus (F-MuLV) was compared with that in mice protected against virus-induced disease by administration of chimpanzee anti-F-MuLV antiserum (CaF-MuLV). Morphologic analysis of glomeruli from viremic (infected) normal chimpanzee serum-treated animals revealed significant renal disease within 2 weeks following virus inoculation, with glomerular immune complex deposits and C-type viral particles seen by electron microscopy. Localization of F-MuLV envelope and core antigens (gp71 and p30, respectively) was also detected by immunofluorescence, as was murine IG and C3. However, age-matched DBA/2 mice treated with CaF-MuLV antiserum alone or following F-MuLV inoculation showed no evidence of systemic disease and neither localization of F-MuLV antigens nor detectable virus particles. These data indicate that in addition to erythroleukemia, F-MuLV infection results in severe immune complex glomerulonephritis and that passive immunotherapy can protect susceptible mice from both aspects of viral pathogenesis.

Original languageEnglish (US)
Pages (from-to)703-717
Number of pages15
JournalJournal of the National Cancer Institute
Volume67
Issue number3
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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