Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance.

Ryan A. Wilcox, Lieping Chen

Research output: Contribution to journalArticle


Human papillomaviruses are associated with a broad range of carcinomas, including cervical cancer. Although the delivery of immunogenic tumor-associated antigens represents a promising approach in the treatment of these malignancies, the imposition of T cell tolerance poses a significant challenge in this endeavor. The purpose of this review is to discuss T cell tolerance and the role of T cell costimulation in the immunotherapy of HPV-associated malignancies.

Original languageEnglish (US)
JournalFrontiers in bioscience : a journal and virtual library
Publication statusPublished - 2002
Externally publishedYes


Cite this