TY - JOUR
T1 - Immunotherapy of cancer using interleukin 2
T2 - current status and future prospects
AU - Rosenberg, Steven A.
PY - 1988/12/1
Y1 - 1988/12/1
N2 - Lymphokine-activated killer (LAK) cells can be isolated as tumor-specific killer cells from a tumor-bearing host, after selective expansion in vitro by culture in interleukin 2 (IL-2). Animal experiments as well as clinical trials have shown that the adoptive transfer of these MHC unrestricted killer cells into tumor bearing hosts can cause the regression of cancer in selected patients. Here, Steven Rosenberg details his group's work on LAK cell therapy, and suggests how the clinical benefits gained so far can be improved upon.
AB - Lymphokine-activated killer (LAK) cells can be isolated as tumor-specific killer cells from a tumor-bearing host, after selective expansion in vitro by culture in interleukin 2 (IL-2). Animal experiments as well as clinical trials have shown that the adoptive transfer of these MHC unrestricted killer cells into tumor bearing hosts can cause the regression of cancer in selected patients. Here, Steven Rosenberg details his group's work on LAK cell therapy, and suggests how the clinical benefits gained so far can be improved upon.
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M3 - Review article
AN - SCOPUS:45549118517
SN - 1471-4906
VL - 9
JO - Trends in Immunology
JF - Trends in Immunology
IS - 1-12
ER -