Abstract
The understanding of the molecular mechanisms of tumor neovascularization has identified several important molecular targets that are specifically expressed on tumor neovasculature but not on physiological neovasculature. These molecular targets can potentially be used in the development of novel therapeutic approaches against tumor angiogenesis. Immunotherapy targeting angiogenesis has emerged as a potentially promising approach compared to the use of angiogenesis inhibitors due to its ability to afford long-term therapeutic protection. This presents remarkable opportunities for the development of innovative cancer therapies.Immunotherapy using DNA vaccines has gained momentum for antiangiogenesis therapy due to their stability, simplicity and excellent safety profile, and may prove to be a potentially useful strategy for targeting angiogenesis. In the current review, we discuss the various strategies and molecular targets employed in the form of DNA vaccines to target: (1) the endothelial cells within the tumor; (2) biological factors important for angiogenesis; and (3) the extracellular matrix and stromal cells associated with the tumor in order to control tumor angiogenesis in preclinical models.
Original language | English (US) |
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Title of host publication | Angiogenesis |
Subtitle of host publication | An Integrative Approach From Science to Medicine |
Publisher | Springer US |
Pages | 451-460 |
Number of pages | 10 |
ISBN (Print) | 9780387715179 |
DOIs | |
State | Published - 2008 |
Keywords
- DNA vaccines
- angiogenesis
- endothelial cells
- immunotherapy
ASJC Scopus subject areas
- General Medicine