Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity

Mark J. Furin, Philip S. Norman, Peter Socrates Creticos, David Proud, Anne Kagey-Sobotka, Lawrence M. Lichtenstein, Robert M. Naclerio

Research output: Contribution to journalArticle

Abstract

We investigated the effect of immunotherapy (IT) on eosinophil (EOS) migration into the nasal cavity after nasal provocation with ragweed antigen and during seasonal exposure. In the first study, three groups of subjects participated: one group with no treatment (N = 19), one group with 10 months of IT, reaching maintenance at 2 μg of Arab a I (antigen E) (N = 15), and one group with 22 months of IT, reaching maintenance at 24 μg of Amb a I (N = 10). The percent of EOSs in nasal lavages performed during December before and 24 hours after nasal challenge with ragweed extract was determined. No significant difference between groups existed before challenge. The no-treatment group demonstrated a significant increase in the percent of EOSs from 26% to 69.5% p <0.008), whereas the treated groups demonstrated no significant change. In the second study, 45 patients were divided into four groups based on maintenance dose in micrograms of Amb a I and duration of treatment: (1) no treatment (N = 15), (2) 1 year at 2 μg (N = 13), (3) 2 years at 2 μg (N = 11), and (4) 3 years at 24 μg (N = 9). Nasal mucosal brushings were done during the ragweed season. A significantly smaller percentage of EOSs in 3-year IT-treated individuals was obtained compared to the control group (18 versus 8.4; p <0.04). The smaller dose of IT, regardless of duration, did not reveal a reduction compared to that in the no-treatment group. These studies provide evidence that IT modifies the eosinophilic response to antigen exposure and demonstrate a parallel between in vivo provocation and seasonal exposure.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Volume88
Issue number1
DOIs
StatePublished - 1991

Fingerprint

Nasal Cavity
Eosinophils
Immunotherapy
Cell Movement
Ambrosia
Antigens
Nose
Maintenance
Nasal Lavage
Therapeutics
Control Groups

Keywords

  • allergic rhinitis
  • Amb a I
  • eosinophils
  • Immunotherapy
  • ragweed

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity. / Furin, Mark J.; Norman, Philip S.; Creticos, Peter Socrates; Proud, David; Kagey-Sobotka, Anne; Lichtenstein, Lawrence M.; Naclerio, Robert M.

In: The Journal of Allergy and Clinical Immunology, Vol. 88, No. 1, 1991, p. 27-32.

Research output: Contribution to journalArticle

Furin, Mark J. ; Norman, Philip S. ; Creticos, Peter Socrates ; Proud, David ; Kagey-Sobotka, Anne ; Lichtenstein, Lawrence M. ; Naclerio, Robert M. / Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity. In: The Journal of Allergy and Clinical Immunology. 1991 ; Vol. 88, No. 1. pp. 27-32.
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abstract = "We investigated the effect of immunotherapy (IT) on eosinophil (EOS) migration into the nasal cavity after nasal provocation with ragweed antigen and during seasonal exposure. In the first study, three groups of subjects participated: one group with no treatment (N = 19), one group with 10 months of IT, reaching maintenance at 2 μg of Arab a I (antigen E) (N = 15), and one group with 22 months of IT, reaching maintenance at 24 μg of Amb a I (N = 10). The percent of EOSs in nasal lavages performed during December before and 24 hours after nasal challenge with ragweed extract was determined. No significant difference between groups existed before challenge. The no-treatment group demonstrated a significant increase in the percent of EOSs from 26{\%} to 69.5{\%} p <0.008), whereas the treated groups demonstrated no significant change. In the second study, 45 patients were divided into four groups based on maintenance dose in micrograms of Amb a I and duration of treatment: (1) no treatment (N = 15), (2) 1 year at 2 μg (N = 13), (3) 2 years at 2 μg (N = 11), and (4) 3 years at 24 μg (N = 9). Nasal mucosal brushings were done during the ragweed season. A significantly smaller percentage of EOSs in 3-year IT-treated individuals was obtained compared to the control group (18 versus 8.4; p <0.04). The smaller dose of IT, regardless of duration, did not reveal a reduction compared to that in the no-treatment group. These studies provide evidence that IT modifies the eosinophilic response to antigen exposure and demonstrate a parallel between in vivo provocation and seasonal exposure.",
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