Immunotherapy and radiation in glioblastoma

Solmaz Sahebjam, Andrew Sharabi, Michael Lim, Pravin Kesarwani, Prakash Chinnaiyan

Research output: Contribution to journalArticlepeer-review

Abstract

Radiation therapy plays a central role in the management of glioblastoma. Although primarily thought of as modality to provide local tumor control through DNA damage, the capacity of ionizing radiation to modulate tumor immune response has long been recognized. The recent emergence of clinically active immunotherapies offers exciting potential for harnessing the immune modulatory effects or radiation through combinatorial strategies designed to enhance clinical outcomes. In this Review, we provide background describing the unique immune environment within the central nervous system, how ionizing radiation may modulate the tumor immune response, preclinical and clinical data testing the combination of radiation and immune modulating agents, and highlight some of the current challenges in extending these findings clinically.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of Neuro-Oncology
DOIs
StateAccepted/In press - May 31 2017

Keywords

  • Glioblastoma
  • Immunotherapy
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Fingerprint Dive into the research topics of 'Immunotherapy and radiation in glioblastoma'. Together they form a unique fingerprint.

Cite this