TY - JOUR
T1 - Immunotherapy and biological modifiers for the treatment of malignant brain tumors
AU - Marras, Carlo
AU - Mendola, Carmela
AU - Legnani, Federico Giuseppe
AU - DiMeco, Francesco
PY - 2003/5
Y1 - 2003/5
N2 - The relative ineffectiveness of current therapies for malignant gliomas has led to the need for novel therapeutics. Therapies based on biologic modifiers are among a variety of cancer treatments currently in use or under experimental evaluation and have shown great promise, especially since several potent stimulators of the immune system have been cloned and are now available for clinical use. Early attempts at glioma therapy based on biologic modifiers, however, have failed to demonstrate significant effectiveness. In this review, we select and summarize the results of preclinical and clinical studies published during the past two years that focus on immunotherapy and biologic modifiers for treating gliomas. Despite limited clinical success, we conclude that an increased understanding of molecular biology and immunology from recent studies may pave the way for more effective approaches.
AB - The relative ineffectiveness of current therapies for malignant gliomas has led to the need for novel therapeutics. Therapies based on biologic modifiers are among a variety of cancer treatments currently in use or under experimental evaluation and have shown great promise, especially since several potent stimulators of the immune system have been cloned and are now available for clinical use. Early attempts at glioma therapy based on biologic modifiers, however, have failed to demonstrate significant effectiveness. In this review, we select and summarize the results of preclinical and clinical studies published during the past two years that focus on immunotherapy and biologic modifiers for treating gliomas. Despite limited clinical success, we conclude that an increased understanding of molecular biology and immunology from recent studies may pave the way for more effective approaches.
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U2 - 10.1097/00001622-200305000-00004
DO - 10.1097/00001622-200305000-00004
M3 - Article
C2 - 12778012
AN - SCOPUS:0038686979
SN - 1040-8746
VL - 15
SP - 204
EP - 208
JO - Current Opinion in Oncology
JF - Current Opinion in Oncology
IS - 3
ER -