Immunosuppressive Effects of Selected Metabolic Inhibitors in Vivo and in Vitro

Noel R. Rose, Judith A. Haber, Paul Calabresi

Research output: Contribution to journalArticle

Abstract

Actinomycin D, puromycin, 6-mercaptopurine, and cytosine arabinoside were shown to decrease the number of plaque-forming units upon in vitro incubation with suspensions of spleen cells taken from sheep-cell immunized mice. Under similar conditions, 5-iodo-2′-deoxyuridine, 5-bromo-2′-deoxyuridine, azauridine, and chloramphenicol had no effect. Administered in vivo, 6-mercaptopurine, cytosine arabinoside, and chloramphenicol all suppressed plaque production. In the case of the latter two antimetabolites, serum antibody titers remained unaffected by the dosages given.

Original languageEnglish (US)
Pages (from-to)1121-1128
Number of pages8
JournalProceedings of the Society for Experimental Biology and Medicine
Volume128
Issue number4
DOIs
StatePublished - Sep 8 1968

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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