Actinomycin D, puromycin, 6-mercaptopurine, and cytosine arabinoside were shown to decrease the number of plaque-forming units upon in vitro incubation with suspensions of spleen cells taken from sheep-cell immunized mice. Under similar conditions, 5-iodo-2′-deoxyuridine, 5-bromo-2′-deoxyuridine, azauridine, and chloramphenicol had no effect. Administered in vivo, 6-mercaptopurine, cytosine arabinoside, and chloramphenicol all suppressed plaque production. In the case of the latter two antimetabolites, serum antibody titers remained unaffected by the dosages given.
|Original language||English (US)|
|Number of pages||8|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Sep 8 1968|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)