Immunosuppressive activity of hymenistatin I

Marek Cebrat, Zbigniew Wieczorek, Ignacy Z. Siemion

Research output: Contribution to journalArticle

Abstract

Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The results are compared with the activity of the well-known immunosuppressive agent cyclosporin A (CsA). It was found that hymenistatin I exerts immunosuppressive effect (both in the humoral and cellular immune responses) comparable with that of CsA. Comparison of the influence of HS-I and CsA on cytokines production suggests that the mechanisms of the interaction with the immunological system are substantially different for the two compounds tested.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalPeptides
Volume17
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Hymenistatin I
  • Immune response
  • Immunopeptides
  • Immunosuppression
  • Interleukins

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Cebrat, M., Wieczorek, Z., & Siemion, I. Z. (1996). Immunosuppressive activity of hymenistatin I. Peptides, 17(2), 191-196. https://doi.org/10.1016/0196-9781(95)02123-X