Immunoregulatory functions of mTOR inhibition

Angus W. Thomson, Heth R. Turnquist, Giorgio Raimondi

Research output: Contribution to journalArticle

Abstract

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of growth factor-induced T cell proliferation. However, it is now evident that the serine/threonine protein kinase mammalian target of rapamycin (mTOR) has an important role in the modulation of both innate and adaptive immune responses. mTOR regulates diverse functions of professional antigen-presenting cells, such as dendritic cells (DCs), and has important roles in the activation of effector T cells and the function and proliferation of regulatory T cells. In this Review, we discuss our current understanding of the mTOR pathway and the consequences of mTOR inhibition, both in DCs and T cells, including new data on the regulation of forkhead box P3 expression.

Original languageEnglish (US)
Pages (from-to)324-337
Number of pages14
JournalNature Reviews Immunology
Volume9
Issue number5
DOIs
StatePublished - May 2009
Externally publishedYes

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Sirolimus
Dendritic Cells
Cell Proliferation
T-Lymphocytes
Protein-Serine-Threonine Kinases
Adaptive Immunity
Antigen-Presenting Cells
Regulatory T-Lymphocytes
Immunosuppressive Agents
Innate Immunity
Intercellular Signaling Peptides and Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Immunoregulatory functions of mTOR inhibition. / Thomson, Angus W.; Turnquist, Heth R.; Raimondi, Giorgio.

In: Nature Reviews Immunology, Vol. 9, No. 5, 05.2009, p. 324-337.

Research output: Contribution to journalArticle

Thomson, Angus W. ; Turnquist, Heth R. ; Raimondi, Giorgio. / Immunoregulatory functions of mTOR inhibition. In: Nature Reviews Immunology. 2009 ; Vol. 9, No. 5. pp. 324-337.
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