Abstract
The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of growth factor-induced T cell proliferation. However, it is now evident that the serine/threonine protein kinase mammalian target of rapamycin (mTOR) has an important role in the modulation of both innate and adaptive immune responses. mTOR regulates diverse functions of professional antigen-presenting cells, such as dendritic cells (DCs), and has important roles in the activation of effector T cells and the function and proliferation of regulatory T cells. In this Review, we discuss our current understanding of the mTOR pathway and the consequences of mTOR inhibition, both in DCs and T cells, including new data on the regulation of forkhead box P3 expression.
Original language | English (US) |
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Pages (from-to) | 324-337 |
Number of pages | 14 |
Journal | Nature Reviews Immunology |
Volume | 9 |
Issue number | 5 |
DOIs | |
State | Published - May 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology