Immunoregulatory effects of PSK on the Th1/Th2 balance and regulatory T-cells in patients with colorectal cancer

Shigefumi Yoshino, Kiyoshi Yoshimura, Nobuaki Suzuki, Michihisa Lida, Shin Yoshida, Yoshinari Maeda, Kazunari Maeda, Shoichi Hazama, Masaaki Oka

Research output: Contribution to journalArticle

Abstract

It is very important for immunotherapy to release Th2-dominated and Treg-dominated immunological conditions in patients with malignant diseases. In the present study, we assessed the population of CD4+IL-10 +T-cells and CD4+Foxp3+ T-cells in peripheral blood in patients with colorectal cancer using a flow cytometric analysis, and we investigated whether Th2-dominated and Treg-dominated condition could be modulated by PSK. Peripheral blood samples were collected pre-operatively from 40 patients with colorectal cancer before and after oral administration of PSK (3g/dayx 1 week). After PSK treatment, CD4+IL-10+T-cell percentages decreased in 63% of patients and CD4+Foxp3 +T-cells percentages decreased in 63% of patients. However, no correlation was found between the ratio of CD4+IL-10 +T-cell percentages and that of CD4+Foxp3 +T-cell percentages after/before PSK treatment. These results suggest that PSK could release Th2-dominated and Treg-dominated immunological condition in patients with colorectal cancer. Further examinations are needed to investigate the after/before percentage ratio of CD4+Foxp3 +T-cells can be useful predicting parameters for the selection of responders of PSK.

Original languageEnglish (US)
Pages (from-to)2234-2236
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume37
Issue number12
StatePublished - 2010
Externally publishedYes

Keywords

  • Colorectal cancer
  • IL-10
  • PSK
  • Treg

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Yoshino, S., Yoshimura, K., Suzuki, N., Lida, M., Yoshida, S., Maeda, Y., Maeda, K., Hazama, S., & Oka, M. (2010). Immunoregulatory effects of PSK on the Th1/Th2 balance and regulatory T-cells in patients with colorectal cancer. Japanese Journal of Cancer and Chemotherapy, 37(12), 2234-2236.