Immunoregulation in TB: Observations and implications

Jerrold J. Ellner

Research output: Contribution to journalArticle

Abstract

Regulation of the immune response during active tuberculosis (TB) has been partly deciphered. In pulmonary TB there is transient systemic immunosuppression due to overexpression of transforming growth factor beta and interleukin-10. This is superimposed on a primary T-cell defect. Locally there is intense inflammation (lung, pleural fluid) with overexpression of immunosuppressive factors (bronchoalveolar lavage) and extensive apoptosis. These observations suggest that immune therapies should be aimed at neutralizing the negative regulatory factors rather than accentuating an already intense immune response. Also a partially effective vaccine carries the potential risk of exacerbating disease.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalClinical and Translational Science
Volume3
Issue number1
DOIs
StatePublished - Feb 2010
Externally publishedYes

Keywords

  • Immuno-pathogenesis
  • Immunoregulation
  • Tuberculosis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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