Immunoreactive neurotensin levels in pancreas: Elevation in diabetic rats and mice

Madelyn Hirsch Fernstrom, Marek A Mirski, Robert E. Carraway, Susan E. Leeman

Research output: Contribution to journalArticle


Neurotensin levels in pancreas, but not other tissues, were increased in diabetic animals. The concentration of pancreatic immunoreactiveneurotensin was 138% higher in streptozotocin-diabetic rats, and 68% higher in genetically diabetic ( db db) mice as compared to their respective control animals. Daily administration of insulin (10-15 IU/kg) to diabetic rats completely reversed this effect, and pancreatic neurotensin levels in these animals returned to control values. These findings suggest that elevated levels of pancreatic neurotensin may contribute to some of the metabolic and hormonal disturbances occurring in diabetes.

Original languageEnglish (US)
Pages (from-to)853-855
Number of pages3
Issue number9
StatePublished - 1981
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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