Immunoprotein Deposition in the Cornea

Kathleen H. Miller; W. Richard Green; Walter J. Stark; Hawey A. Wells; Geoffrey Mendelsohn; Harry Kanhofer

doi:10.1016/S0161-6420(80)35154-3

Immunoprotein Deposition in the Cornea

Kathleen H. Miller, W. Richard Green, Walter J. Stark, Hawey A. Wells, Geoffrey Mendelsohn, Harry Kanhofer

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A 63-year-old woman had bilateral, multi-level corneal deposits distributed as fine, discrete crystals and in dense, deep geographic patches. She had a long history of sero-positive rheumatoid arthritis. Autopsy revealed an unsuspected lymphoproliferative disorder and immune-complex disease. Histologic examination of the eyes revealed eosinophilic, PAS-positive, noncollagenous deposits in the cornea at all levels and also in the ciliary processes, pars plana, and choroid. Stains for gold, amyloid, and acid mucopolysaccharides were negative. Immunoperoxidase stains were positive for IgG most strongly, and also for IgA, kappa and lambda light chains. Transmission electron microscopy showed needle-like electron-dense extracellular particles which we presume are immunoglobulins.

Original language	English (US)
Pages (from-to)	944-950
Number of pages	7
Journal	Ophthalmology
Volume	87
Issue number	9
DOIs	https://doi.org/10.1016/S0161-6420(80)35154-3
State	Published - 1980
Externally published	Yes

Keywords

Bietti's crystalline dystrophy
Schnyder's crystalline dystrophy
benign monoclonal gammopathy
chrysiasis
corneal crystalline deposits
cystinosis
immunoperoxidase stains
immunoprotein
multiple myeloma

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(80)35154-3

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@article{b9bfdaa1113647f9bb258c4c71103e29,

title = "Immunoprotein Deposition in the Cornea",

abstract = "A 63-year-old woman had bilateral, multi-level corneal deposits distributed as fine, discrete crystals and in dense, deep geographic patches. She had a long history of sero-positive rheumatoid arthritis. Autopsy revealed an unsuspected lymphoproliferative disorder and immune-complex disease. Histologic examination of the eyes revealed eosinophilic, PAS-positive, noncollagenous deposits in the cornea at all levels and also in the ciliary processes, pars plana, and choroid. Stains for gold, amyloid, and acid mucopolysaccharides were negative. Immunoperoxidase stains were positive for IgG most strongly, and also for IgA, kappa and lambda light chains. Transmission electron microscopy showed needle-like electron-dense extracellular particles which we presume are immunoglobulins.",

keywords = "Bietti's crystalline dystrophy, Schnyder's crystalline dystrophy, benign monoclonal gammopathy, chrysiasis, corneal crystalline deposits, cystinosis, immunoperoxidase stains, immunoprotein, multiple myeloma",

author = "Miller, {Kathleen H.} and Green, {W. Richard} and Stark, {Walter J.} and Wells, {Hawey A.} and Geoffrey Mendelsohn and Harry Kanhofer",

note = "Funding Information: Supported in part by Research Grant 1 R01 EY 01684-03 from the National Eye Institute, US Public Health Service. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1980",

doi = "10.1016/S0161-6420(80)35154-3",

language = "English (US)",

volume = "87",

pages = "944--950",

journal = "Ophthalmology",

issn = "0161-6420",

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T1 - Immunoprotein Deposition in the Cornea

AU - Miller, Kathleen H.

AU - Green, W. Richard

AU - Stark, Walter J.

AU - Wells, Hawey A.

AU - Mendelsohn, Geoffrey

AU - Kanhofer, Harry

PY - 1980

Y1 - 1980

N2 - A 63-year-old woman had bilateral, multi-level corneal deposits distributed as fine, discrete crystals and in dense, deep geographic patches. She had a long history of sero-positive rheumatoid arthritis. Autopsy revealed an unsuspected lymphoproliferative disorder and immune-complex disease. Histologic examination of the eyes revealed eosinophilic, PAS-positive, noncollagenous deposits in the cornea at all levels and also in the ciliary processes, pars plana, and choroid. Stains for gold, amyloid, and acid mucopolysaccharides were negative. Immunoperoxidase stains were positive for IgG most strongly, and also for IgA, kappa and lambda light chains. Transmission electron microscopy showed needle-like electron-dense extracellular particles which we presume are immunoglobulins.

AB - A 63-year-old woman had bilateral, multi-level corneal deposits distributed as fine, discrete crystals and in dense, deep geographic patches. She had a long history of sero-positive rheumatoid arthritis. Autopsy revealed an unsuspected lymphoproliferative disorder and immune-complex disease. Histologic examination of the eyes revealed eosinophilic, PAS-positive, noncollagenous deposits in the cornea at all levels and also in the ciliary processes, pars plana, and choroid. Stains for gold, amyloid, and acid mucopolysaccharides were negative. Immunoperoxidase stains were positive for IgG most strongly, and also for IgA, kappa and lambda light chains. Transmission electron microscopy showed needle-like electron-dense extracellular particles which we presume are immunoglobulins.

KW - Bietti's crystalline dystrophy

KW - Schnyder's crystalline dystrophy

KW - benign monoclonal gammopathy

KW - chrysiasis

KW - corneal crystalline deposits

KW - cystinosis

KW - immunoperoxidase stains

KW - immunoprotein

KW - multiple myeloma

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DO - 10.1016/S0161-6420(80)35154-3

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AN - SCOPUS:0019161137

SN - 0161-6420

VL - 87

SP - 944

EP - 950

JO - Ophthalmology

JF - Ophthalmology

IS - 9

ER -

Immunoprotein Deposition in the Cornea

Abstract

Keywords

ASJC Scopus subject areas

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